ECE2015 Guided Posters Steroids (9 abstracts)
Differential regulation of 11β-hydroxysteroid dehydrogenase type 1 activity in patients with differing aetiologies of hypopituitarism
Lucy Ann Behan 1 , Bairbre Rogers 1 , K Maher 2 , Norman F Taylor 3 , Diarmuid Smith 1 , Chris J Thompson 1 , John P Monson 2 & Amar Agha 1
1Department of Endocrinology, Beaumont Hospital and RCSI Medical School, Dublin, Ireland; 2Department of Endocrinology and Chemical Pathology, St Bartholomew’s Hospital, London, UK; 3Department of Endocrinology and Chemical Pathology, King’s College Hospital, London, UK.
Pituitary patients with different aetiologies of hypopituitarism exhibit differing phenotypes despite optimal replacement therapy. We hypothesised that differential regulation of the isoenzyme 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which mediates the autocrine conversion of cortisone to cortisol in adipose tissues and liver may play a role.
We prospectively studied 11β-HSD1 activity through analysis of 24 h urine cortisol/cortisone metabolites ratio (Table 1). 36 hypopituitary patients with craniopharyngioma, treated remitted Cushing’s disease and non-functioning pituitary adenomas or prolactinomas (NFPA or PRL) were studied, on and off GH replacement.
11β-HSD1 activity was higher in subjects with craniopharyngioma both on and off GH evidenced by increased tetrahydrocortisol to tetrahydrocortisone metabolite (THF+5alloTHF/THE) ratio compared to other diagnostic groups (Table 1). There was no difference in BMI, insulin levels, serum hormone measurements, or hydrocortisone dose between groups.
| Craniopharyngioma (n=9) | Treated Cushing’s disease (n=8) | NFPA or PRL (n=19) | |
| THF+5alloTHF/THE On GH | 1.23 (0.8–1.4) | 0.97 (0.44–1.1) | 0.73 (0.61–1.04)* |
| THF+5alloTHF/THE Off GH | 1.3 (0.9–1.4) | 0.94 (0.49–1.08)* | 0.79 (0.66–1.09)† |
| Data are median (interquartile range), *P<0.05 and †P<0.01 are compared to craniopharyngioma. | |||
Craniopharyngioma is associated with altered enhanced 11β-HSD1 activity compared to other diagnostic groups and this may contribute to the altered body composition seen in this condition.
Disclosure: This work was supported by an unrestricted educational grant from Novo Nordisk Ireland.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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