ECE2015 Guided Posters Reproduction: Female and PCOS (8 abstracts)
Phenotypic characteristic of type 1 diabetic women with polycystic ovary syndrome
Agnieszka Lebkowska 1 , Agnieszka Adamska 1 , Monika Karczewska-Kupczewska 2, , Agnieszka Nikolajuk 3 , Elzbieta Otziomek 1 , Robert Milewski 4 , Slawomir Wolczynski 5 , Maria Gorska 1 & Irina Kowalska 1
1Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland; 2Department of Metabolic Diseases, Medical University of Bialystok, Bialystok, Poland; 3Department of Prophylaxis of Metabolic Diseases, Institut of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland; 4Department of Statistics and Medical Informatics, Medical University of Bialystok, Bialystok, Poland; 5Department of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Bialystok, Poland.
Introduction: The prevalence of polycystic ovary syndrome (PCOS) is increased in women with type 1 diabetes (T1DM) in comparison to the general population. It has been suggested that exogenous insulin administered to T1DM women in supraphysiological doses could act as co-gonadotropin and lead to disturbances observed in PCOS.
Aim: The aim of this study was to evaluate the phenotypic characteristic and differences between diabetic women with PCOS (T1DM+PCOS) and age-, BMI-matched women with type 1 diabetes without PCOS (T1DM-no PCOS) and non-diabetic women with PCOS (PCOS).
Study participants and methods: We studied 108 women: 39 with T1DM (18 with T1DM+PCOS and 21 with T1DM-no PCOS), 47 with PCOS and 22 healthy women. PCOS was diagnosed using the Rotterdam criteria. The anthropometric measurements, clinical parameters, estimation of plasma concentrations of sex hormones, SHBG, HbA1c and ultrasonographic evaluation of the ovaries were performed for all women. In both diabetic groups insulin sensitivity was calculated with estimated glucose disposal rate (eGDR).
Results: There were no significant differences in anthropometric measurements between all studied groups. The Ferriman–Gallwey score was higher in women with PCOS than in those with PCOS+T1DM (P=0.074). Hormonal profile was similar in both groups with PCOS. We observed that ovarian volume and ovarian follicle count did not differ in patients with PCOS+T1DM and PCOS. The number of ovarian follicles was higher in the PCOS+T1DM and PCOS groups versus the control (P=0.008, P<0.001) and versus the T1DM/no-PCOS group (P<0.001, P<0.001, respectively). HbA1c, daily insulin dose, eGDR were not different between PCOS+T1DM and T1DM-no PCOS. A significant negative relationship of eGDR with body fat mass and BMI was found in T1DM+PCOS (r=−0.75, P<0.001; r=−0.75, P<0.001), which was not observed in patients with T1DM-no PCOS.
Conclusion: We conclude, that phenotypic characteristic of T1DM+PCOS women is similar to PCOS. Further study are required to better understand the pathogenesis of PCOS in type 1 diabetic women.
Disclosure: This work was supported by the Medical University of Bialystok in Poland (grant number 123-50722L).
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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