ECE2015 Guided Posters Diabetes and obesity – Translational diabetes (7 abstracts)
GLP-1 (Active 7-36) secretory response after test meal in obese patients before and 5; 90 and 180 days after bariatric gastric bypass surgery
Dragan Micic 1 , Snezana Polovina 1 , Mirjana Sumarac-Dumanovic 1 , Pavle Gregoric 2 , Goran Cvijovic 1 , Svetlana Ignjatovic 1 , Marjana Dajak 1 , Dusan Micic 2 , Danica Stamenkovic-Pejkovic 1 & Danka Jeremic 1
1Clinic for Endocrinology, Diabetes and Diseases of Metabolism, Clinical Center of Serbia, Belgrade, Serbia; 2Emergency Center, Clinical Center of Serbia, Belgrade, Serbia.
There are different explanations concerning observed improvement of glucose control after baiatric gatric bypass surgery. The aim of our study was to investigate GLP-1 response after test meal (Fresubin drink a 200 ml; 200 kcal, 15% protein, 30% fat and 55% carbohydrate) before (day 0) and 5; 90 and 180 days after gastric bypass surgery. Glycaemia (mmol/l; glucose oxidase) and GLP-1 (Active 7-36) (pM/l; ELISA, ALPCO diagnostics) were determined in 41 obese patients (age: 37.86±11.21 years; BMI: 43.45±4.91 kg/m2) in four separate days in 0, 15, 30, 45, 60, 90 and 120 min. There were significant decrease in the area under the glucose curve (X± S.D.) (664.70±186.81 vs 636.45±177.35 vs 501.50±90.17 vs 507.41±80.08 mmol/l per min; P<0.05) in respective day intervals, while there was significant increase in area under the GLP-1 curve (pmol/l per min) in days 5 (919.19±653.73), day 90 (682.92±489.79) and day 180 (789.41±558.56) in comparison with day 0 (279.80±429.97) (P< 0.05). There were no significant differences between basal glucose and GLP-1 levels (1.67±2.64; 1.33±2.12; 2.06±2.75; P> 0.05) except for day 180 (3.52±3.92 P<0.05) while there was significant increase in peak GLP-1 levels in day 5 (17.12±8.99), day 90 (14.44±8.75) and day 180 (17.25±10.52) during response after test meal in comparison with day 0 (3.82±3.95) (P<0.05). In conclusion, GLP-1 response after test meal is significantly increased after gastric bypass surgery early (after 5 days) and lately (after 90 and 180 days). The improvement in GLP-1 response after test meal after gastric bypass surgery may be contribute to the beneficial metabolic effects of bariatric surgery, especially concerning glucose control.
Volume 37
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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