ECE2015 Guided Posters Diabetes and obesity – Translational diabetes (7 abstracts)
Telomere biology and vascular ageing in patients with T2DM
Nataliia Brailova 1 , Ekaterina Dudinskaya 1 , Irina Strazhesko 1 , Dariga Akasheva 1 , Marina Pokrovskaya 1 , Olga Tkacheva 1 , Sergei Boytsov 1 , Marina Shestakova 2 & Vladimir Vigodin 1
1National Research Centre for Preventive Medicine, Moscow, Russia; 2National Research Centre for Endocrinology, Moscow, Russia.
It is known that glucose disturbances contribute to vascular ageing. The length of telomere (TL) and telomerase activity (TA) are considered as biomarkers of cellular ageing. It is crucial to determine the role of telomere biology in different vessels changes in diabetic patients. The aim of our study was to determine the role of telomere biology in vascular ageing in patients with T2DM.
Results: All patients were divided into two groups by the median of TL (9.75): «short» telomeres and «long» telomeres. Vessels changes were more pronounced in patients with «short» TL: PWV 14.11±3.22 m/s vs 11.78±3.26 m/s (P=0.016), IMT 1.00±0.15 mm vs 0.84±0.16 mm (P=0.0010), PP 2.63±0.31 vs 1.36±0.26 (P=0.0032), FMV 7.93±3.40 vs 10.95±3.10 (P=0.0022), NDV 12.63±4.25 vs 15.68±4.51 (P=0.0186). TA was similar in the two groups. We found increasing of oxidative stress and chronic inflammation in diabetic patients with «short» TL: MDA 3.43±1.06 mkmol/l vs 2.94±0.87 mkmol/l (P=0.058); CRP 9.43±2.01 mg/l vs 3.30±0.37 mg/l (P=0.0062). Correlation analysis showed significant association between TL and next parameters: PWV (r=−0.50, P=0.0003), IMT (r=−0.39, P=0.0059), FMV (r=0.49, P=0.0003), NDV (r=0.41, P=0.0035), FPG (r=−0.42, P=0.0027), CRP (r=−0.40, P=0.0039), TA (r=−0.32, P=0.0353).
Conclusion: In patients with T2DM and ‘short’ telomeres signs of vascular ageing, chronic inflammation and oxidative stress were more pronounced. Perhaps long telomeres protect vessels of patients with T2DM from accelerated vascular ageing.
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Endocrine Abstracts
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