Endocrine Abstracts

Purpose: The purpose of this study was to analyse ghrelin concentrations in the umbilical cord of pregnant women with a diagnosis of gestational diabetes mellitus. The relationship between ghrelin concentrations and birth weights was investigated.Methods: Sixty pregnant women with gestational diabetes mellitus and 64 healthy pregnant women with three oral glucose tolerance test results within normal limits were included in the study. Following birth but ...

Introduction: Embryonal antitumour modulator of Mkrtchyan (EATM) reveals a hypoglycemic effect in streptozotocin-induced diabetes in rats. The aim of the work was to determine the influence of EATM on the process of releasing of Nox of erythrocyte membranes (EM) and serum of patients with diabetes type 1 and 2.Materials and methods: The study included 12 patients with type 1 diabetes, 12 patients with type 2 diabetes and 12 healthy volunteers. Isolation ...

The exact mechanism of the development of T2DM is still unclear, however, it is known that important role is played by both environmental and genetic factors. In this study we focused on describing the interactions between environmental and genetic factors and answering the question whether physical activity can modify the impact of the genes on the incidence of T2DM. We recruited 921 subjects (median age: 38 years; 49.7% man; mean BMI: 28.1) from the cohort 1000 Polish Longit...

Introduction: There is a growing interest in cell-based therapies in T2DM as β-cell failure is progressive and inexorable. This study evaluates the efficacy of autologous bone marrow-derived mesenchymal stem cell transplantation (ABM-MSCT) in T2DM.Methods: This prospective, randomised, single-blinded placebo-controlled study enrolled 20 patients with triple oral hypoglycaemic drug failure and requiring insulin ≥0.4 Units/kg per day for achievi...

It is known that glucose disturbances contribute to vascular ageing. The length of telomere (TL) and telomerase activity (TA) are considered as biomarkers of cellular ageing. It is crucial to determine the role of telomere biology in different vessels changes in diabetic patients. The aim of our study was to determine the role of telomere biology in vascular ageing in patients with T2DM.Results: All patients were divided into two groups by the median of ...

Introduction: T1DM is a risk factor for reduced bone mass, disrupting several bone metabolic pathways. Dickkopf-1 is an inhibitor of the Wnt/b-catenin bone metabolic pathway. Increased fracture risk and elevated Dickkopf-1 levels have been documented in adult patients with T2DM. No relevant data exist on childhood T1DM. Our aim was to study plasma Dickkopf-1 concentration in children and adolescents with T1DM and controls and to correlate Dickkopf-1 levels with metabolic bone ...

There are different explanations concerning observed improvement of glucose control after baiatric gatric bypass surgery. The aim of our study was to investigate GLP-1 response after test meal (Fresubin drink a 200 ml; 200 kcal, 15% protein, 30% fat and 55% carbohydrate) before (day 0) and 5; 90 and 180 days after gastric bypass surgery. Glycaemia (mmol/l; glucose oxidase) and GLP-1 (Active 7-36) (pM/l; ELISA, ALPCO diagnostics) were determined in 41 obese patients (age: 37.86...