ECE2015 Guided Posters Diabetes and obesity – Clinical diabetes (8 abstracts)
The effect of Roux-en-Y gastric bypass, sleeve gastrectomy and adjustable gastric banding on renal function and remission of metabolic disease: a five-year longitudinal study
Karl Neff 1 , Gregory Baud 2 , Violeta Raverdy 2 , Carel le Roux 1 & Francois Pattou 2
1Diabetic Complication Research Centre, UCD Conway Institute, School of Medicine and Medical Science, University College Dublin, Dublin, Ireland; 2Department of General and Endocrine Surgery, Lille University Hospital, Lille, France.
Introduction: There are few data on renal function following bariatric surgery. We evaluated the effect of Roux-en-Y gastric bypass (RYGB), adjustable gastric banding (AGB) and sleeve gastrectomy (SG) on renal function over a 5-year post-operative period. We also evaluate the effect of these procedures on remission of diabetes and hypertension.
Methods: Analysis of a prospectively collected database at Lille University Hospital. Patients were assessed pre-operatively and then at 1 and 5 years post-operatively.
Results: Subject undergoing RYGB (n=190), AGB (n=271) and SG (n=16) were included. Estimated glomerular filtration rate (eGFR) increased following RYGB (95+/−2 to 101+/−1, P=0.01) and AGB: 88+/−1 to 93+/−2, P=0.02). In those with eGFR <60 ml/min per 1.73 m2 at baseline, eGFR improved over 5 years (52+/−2 to 68+/−7 ml/min per 1.73 m2, P=0.01). RYGB induced remission of diabetes and pre-diabetes to a greater extent than AGB (43% vs 15%; P<0.001). Remission of hypertension was also greater in the RYGB group at year 1 (32% vs 16%, P=0.008) and year 5 (23% vs 11%, P=0.02).
Conclusions: Bariatric surgery maintains eGFR over time. This may be due to the effect on blood pressure and glycaemia.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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