ECE2015 Guided Posters Diabetes and obesity – Clinical diabetes (8 abstracts)
Changes of metabolic syndrome and its components in early adolescents through a 9.9 year community-based lifestyle intervention: Tehran Lipid and Glucose Study
Parisa Amiri 1, , Sara Jalali-Farahani 1, , Sakine Hanifi 1, , Leila Cheraghi 1, , Amir Abbas Momenan 3 , Firoozeh Hosseini-Esfahani 4 , Parvin Mirmiran 4 , Arash Ghanbarian 3 & Fereidoun Azizi 5
1Research Center for Social Determinants of Endocrine Health, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 5Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Introduction: To assess the effect of community-based multidisciplinary lifestyle interventions on metabolic syndrome (MetS) and its components in an urban population of Iranian adolescents.
Methods: This longitudinal study was conducted on 1230 adolescents, aged 12–15 years, within the framework of the TLGS. They were categorised in three groups: those residing in the intervention area during study (complete intervention group; n=195); those residing in the intervention area at baseline and at least one follow-up (incomplete intervention group; n=459) and control group (n=576). After baseline assessments (1999–2001), all measurements were repeated every 3 years for up to 9 years. Lifestyle interventions were aimed at achieving healthy dietary patterns and increasing the level of physical activity. The MetS has been defined using Cook definition. Generalised estimating Default (GEE) models were used to analyse data.
Results: Around 6.4, 25.3 and 10.8% of participants were lost to follow-up in control, incomplete and complete intervention groups respectively. Using GEE, at the end of study in boys, overall means of FPG were significantly lower in those who were placed in both intervention groups, compared with controls (β=−3.36 and −2.28 respectively). However, in girls only the complete intervention group had significantly lower FPG mean, vs controls (β=−2.32). In both boys and girls, mean TG was significantly lower in the complete intervention group vs controls (β=−14.33 and β=−8.50 respectively). Compared with the control group, mean SBP was significantly lower in girls of the complete intervention group (β=−2.56). Compared to controls, HDL was significantly higher in girls who received incomplete β=2.17). Among girls, the complete intervention group was less likely to have MetS and central obesity than the control group (OR=0.23 and OR=0.32 respectively; P<0.05).
Conclusion: Community-based lifestyle interventions reduced the risk of MetS and central obesity in girls and improved the means of cardio-metabolic risk factors in both sexes over the study period.
Disclosure: This research has been granted by Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences.
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