Endocrine Abstracts

Introduction: Mean platelet volume (MPV) which is part of a complete blood count measures the platelet size. There are many studies in the literature that it is an indicator of platelet function in thrombotic and inflammatory diseases. However, the number of studies about changes in MPV after treatment in thyroid disease is very limited. In this study, we aimed to reveal the MPV change with treatment in patients with hypothyroidism and hyperthyroidism.

Materials and methods: After approval from the ethics committee 400 patients (mean age: 51.24±13.62) were retrospectively examined. Two groups were created as 200 patients (21 males and 179 females) with hypothyroidism and 200 patients (26 males and 174 females) with hyperthyroidism. Regularly followed up patients having no other inflammatory acute and chronic disease and without malignancy were included in the study. Before and after treatment in the outpatient follow MPV and TSH values were compared.

Results: TSH level is found 9.54 and 2.18 μIU/ml pre-treatment and post-treatment period respectively (P<0.001) in hypothyroid patients. Pre-treatment TSH level is 0.09 μIU/ml and also post-treatment level is 0.62 μIU/ml (P<0.001) in hyperthyroidism group. There is significant difference between MPV values before and after treatment in hypothyroidism and hyperthyroidism group and also MPV values increased in both groups after treatment (P=0.001).

Conclusion: It is known that MPV decreases in inflammatory events and MPV increases with regression of inflammation. Those results of hypothyroidism which is in group of autoimmune thyroid diseases can be interpreted in terms of the presence of inflammation. The reason for the changes in MPV in our study can be explained in terms of the effect of the treatment of inflammatory period.