ECE2015 Eposter Presentations Thyroid (non-cancer) (160 abstracts)
Pseudothrombocytopenia improved with antithyroid treatment in Graves' disease: a case report
Mehmet Muhittin Yalcin 1 , Fusun Balos Toruner 1 , Emre Arslan 1 , Alev Altinova 1 , Zubeyde Saygili 2 , Sena Aksoy 2 , Mujde Akturk 1 , Zeynep Arzu Yegin 3 & Nuri Cakir 1
1Gazi University Faculty of Medicine Department of Endocrinology and Metabolism, Ankara, Turkey; 2Gazi University Faculty of Medicine Department of Internal Medicine, Ankara, Turkey; 3Gazi University Faculty of Medicine Department of Hematology, Ankara, Turkey.
Thrombocytopenia can be seen rarely in Graves disease (GD). In this report we present a case of pseudothrombocytopenia in a 21-year-old woman who had hyperthyroidism due to GD. A 21-year-old female admitted to our clinic with symptoms such as hair loss, anxiety, nervousness and tremor in hands. Considering her symptoms, thyroid function tests were evaluated to screen for presence of hyperthyoidism. Her TSH level was low while free T3 and free T4 levels were elevated. There was no nodules seen in her thyroid ultrasonography. An increased radioiodine uptake was found in thyroid gland. Her thyroid receptor antibody (TRAB) was positive. In the light of all these results, GD was diagnosed. Before antithyroid treatment, a complete blood count and liver function tests were ordered. All the tests were normal except low platelet count. She had no bleeding history. Test was reordered using a citrate-containing tube and platelets were found low again. Aggrevated platelets were seen in peripheral smear showing that decreased platelet level was due to pseudothrombocytepenia. There was no history of herbal drugs,medicine or any other cause of pseudothrombocytopenia. Methimazole treatment was started. One month after therapy, thyroid function tests came back to normal levels, and TRAB turned to be negative. Interestingly platelet count were turned to be normal in blood tests using both EDTA-containing and citrate-containing tube. Repeated peripheral smear did not contain any aggregation of platelets. Pseudothrombocytopenia was described in only a few case reports in the active phase of some autoimmune diseases like systemic lupus eritamatosis. Our case is the first report of pseudothrombocytopenia in GD. We think that normalisation of platelet count after successful antithyroid treatment is important in the evaluation of these patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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