ECE2015 Eposter Presentations Thyroid (non-cancer) (160 abstracts)
Serum total sialic acid levels in overt and subclinical hypothyroid patients and its relationship with atherosclerotic risk factors
Mustafa Altay 1 , Mehmet Ayhan Karakoç 1 , Nuri Çakır 1 , Etem Turgay Cerit 1 , Müjde Aktürk 1 , Canan Yılmaz Demirtaş 2 , Neslihan Bukan 2 & Metin Arslan 1
1Gazi University Medical Faculty, Department of Endocrinology and Metabolism, Ankara, Turkey; 2Gazi University Medical Faculty, Clinical Biochemistry, Ankara, Turkey.
Objective: Serum total sialic acid(SA) concentration is assessed as an up to date risk indicator of atherosclerosis and cardiovascular diseases.
Methods: It was aimed to investigate about how SA levels are effected in overt or subclinical hypothyroidism (SH) and how it’s associated with other atherosclerosis risk factors because there is no study about these topics, though SA is intensively studied in recent years.
Patients: Sixty newly diagnosed treatment-naive hypothyroid patients (35 subclinical and 25 overt) and 30 euthyroid individuals were included in the study. Fasting blood samples were taken and SA, serum homocystein and hsCRP was measured in addition to routine biochemical measurements and carotid artery intima media thickness (CIMT) measurements were performed.
Results: Diastolic blood pressure, CIMT, Total-C, LDL-C, TG levels were significantly increased in patients. Other atherogenesis related measurements such as systolic blood pressure, uric acid, hsCRP and homocystein levels were also increased in patients, but not statistically significant. Serum total SA levels were higher in hypotyroid patients compared to controls but the difference was not statistically significant. In patients’ group positive correlation between CIMT and SA was determined as it was between SA and uric acid.
Conclusions: Interesting result of our study is the positive relationship between SA and CIMT which is revealed for the first time. The existence of correlation between SA and some indicators like CIMT, hsCRP and uric acid in hypothyroid group suggests that it can be an atherogenesis indicator in hypotyroid patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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