ECE2015 Eposter Presentations Thyroid (non-cancer) (160 abstracts)
False negatives and reasons: Erzurum Research and Training Hospital Pathology Department experience
Sevilay Ozmen 1 , Ilknur Calik 1 , Senay Erdogan 1 , Ozge Timur 2 , Hakan Sevimli 2 , Ayse Carlioglu 3 , Senay Arikan Durmaz 3 & Fazli Erdogan 1
1Department of Pathology, Training and Research Hospital, Erzurum, Turkey; 2Department of Internal Medicine, Training and Research Hospital, Erzurum, Turkey; 3Department of Endocrinology, Training and Research Hospital, Erzurum, Turkey.
Fine-needle aspiration biopsies (FNAB), adequate for examination, reported as benign re-evaluated with histopathological samples. 61 patients, 52 females and nine males re-evaluated. 41 of them reported as benign. 20 of the patients, seven females and three males reported as papillary carcinoma. Six of the papillary carcinomas were single focus, two muiticentric, and 12 papillary microcarcinoma. Six of the eight patients malignant lobe was different from the lobe that FNA was made. Multicentric malignancy was detected in two cases. Malignant FNA diagnosis forms 4–8% of all thyroid FNAs, as in literature. Most of them are papillary thyroid carcinoma (PTC). In fact PTC cytopathological features are quite obvious, at the level of diagnostic. Patients diagnosed PTC with FNAB showed PTC at the rate of 96–100% with histopathological samples. However, false-negative value was 32.78% in our patients under observation. This value is over the false-negative rate ranging between 1 and 21.3% stated in the literature. However, the results of the histopathological report with the results of cytopathological reports examined in detail the majority of the cases with false-negative study (60%) constitute papillary microcarcinoma. This finding suggests that PTC is overlooked with FNAB. Our false-negative rates are compatible with the literature as PTC excluded. Another reason for our false-negative value is the patchy distribution of PTC in the same nodule. As a result, FNAB accompanied with ultrasound, should be applied to all solid, hypoechoic nodules and nodules with microcalcification. Also, because of the presence of PTC showing a patchy distribution in a single nodule, multiple biopsies should be taken from more than one areas, from the large nodules seen sonographically suspicious.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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