Endocrine Abstracts

Inflammation has been shown in obese patients in previous studies. Sick euthyroid syndrome is an expected condition in case of inflammatory diseases. In this study, we aimed to investigate the frequency of sick euthyroid syndrome in obese patients without comorbidities and evaluate the association between obesity and inflammation. A total of 390 subjects were enrolled in this case-control study. The study group consisted of 200 obese patients without comorbidities and the control group consisted of 190 healthy subjects. Thyroid function tests, fasting glucose, insulin, serum lipids, complete blood count, erythrocyte sedimentation rate and hs-CRP levels of all patients were measured. Blood pressures, waist circumference, body mass index were reported. Groups were compared according to the hs-CRP levels and the frequency of sick euthyroid syndrome. The association between hs-CRP and sick euthyroid syndrome was evaluated. The groups were matched in terms of age and sex (P=0.082, 0.186 respectively). There was statistically significant difference between the groups according to the frequency of sick euthyroid syndrome (P<0.001). There was a correlation between the levels of FT₃ and hs-CRP in obese patients with sick euthyroid syndrome (P=0.006). In this study, we have found an association between sick euthyroid syndrome and obesity. Moreover, we have found a correlation between sick euthyroid syndrome and hs-CRP level. These results showed that obesity (without any comorbidities) is an inflammatory disease and has systemic effects which lead to sick euthyroid syndrome (P=0.006). In this study, we have found an association between sick euthyroid syndrome and obesity. Moreover, we have found a correlation between sick euthyroid syndrome and hs-CRP level. These results showed that obesity (without any comorbidities) is an inflammatory disease and has systemic effects which lead to sick euthyroid syndrome.