ECE2015 Eposter Presentations Thyroid (non-cancer) (160 abstracts)
IL-2, IL-4, IL-5, IFN-γ and TNF-α levels in Turkish patients with Hashimoto's thyroiditis
Guzin Fidan Yaylali 1 , Bedia Guleryuz 2 , Fulya Akin 1 , Sebahat Turgut 3 , Senay Topsakal 1 , Melek Tunc Ata 3 & Mukaddes Mengen Dalyanoglu 3
1Department of Endocrinology and Metabolism, Faculty of Medicine, Pamukkale University, Denizli, Turkey; 2Department of Internal Medicine, Faculty of Medicine, Pamukkale University, Denizli, Turkey; 3Department of Physiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Background: Hashimoto’s thyroiditis (HT) is one of the most common autoimmune thyroiditis that characterised by lymphocytic infiltration and thyroid hormonal disturbances. Genetic and environmental factors play a role in etiology of the disease, but genetic factors are most common. In this study, we investigated the association between Hashimoto’s thyroiditis and IL-2, IL-4, IL-5, TNF-α and IFN-γ levels.
Methods: We performed a case–control study that included 139 cases with HT (50 euthyroid, 50 subclinical hypothyroid, 39 overt hypothyroid patients) and 50 healthy control. Subjects were collected from Endocrinology Clinic of Pamukkale University in Turkey. Serum levels of glucose, insulin, PTH, Ca, phosphorus (P), alkaline phosphatase (ALP) were measured and IL-4, IL-5, TNF-α, IFN-γ analysis were performed with ELISA.
Results: IL-2, IL-4, TNF-α and IFN-γ levels were significantly higher in Hashimoto’s thyroiditis patients, there were no significant differences between the groups regarding IL-5 levels. There were no significant differences detected in PTH, ALP and Ca levels.
Conclusion: Because of the HT is an inflammatory disease significantly high IL-2, IL-4, TNF-α and IFN-γ level were observed in HT. Practitioners should take into consideration IL-2, IL-4, TNF-α and IFN-γ levels in HT diagnosis. These inflammatory markers may have an important role in the pathogenic pathway in HT.
Disclosure: Grant numbers 2012 TPF6.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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