ECE2015 Eposter Presentations Thyroid (non-cancer) (160 abstracts)
Triiodothyronine is independently associated with metabolic syndrome in euthyroid middle-aged subjects
Hye Jeong Kim 1 , Hyeong Kyu Park 1 , Dong Won Byun 1 , Kyoil Suh 1 , Myung Hi Yoo 1 , Jae Hyeon Kim 2 , Yong-Ki Min 2 , Sun Wook Kim 2 & Jae Hoon Chung 2
1Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea; 2Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Background: Recent studies have shown associations of thyroid hormone levels with metabolic syndrome (MetS) among euthyroid individuals, though there have been some inconsistencies. We evaluated the relationships between thyroid hormones and MetS in euthyroid middle-aged subjects in a large cohort.
Methods: Retrospective analysis of 13 496 euthyroid middle-aged subjects who participated in comprehensive health examinations was performed. Subjects were grouped according to TSH, total triiodothyronine (T3), total thyroxine (T4), and T3–T4 ratio quartile categories. We estimated the odds ratios (OR) for MetS according to thyroid hormone quartiles using logistic regression models, adjusted for potential confounders.
Results: Twelve percent (n=1664) of the study subjects had MetS. Higher T3 levels and T3– T4 ratio were associated with unfavorable metabolic profiles, such as higher BMI, systolic and diastolic BP, triglycerides, fasting glucose and HbA1c, and lower HDL cholesterol. The proportion of participants with MetS increased across the T3 quartile categories (P for trend <0.001) and the T3–T4 ratio quartile categories (P for trend <0.001). The multivariate-adjusted OR (95% CI) for MetS in the highest T3 quartile group was 1.249 (1.020–1.529) compared to the lowest T3 quartile group, and that in the the highest T3–T4 ratio quartile group was 1.458 (1.141–1.863) compared to the lowest T3–T4 ratio quartile group, even after adjustment for sex, age, body fat percentage, smoking, and HOMA-IR.
Conclusions: Serum T3 levels and T3–T4 ratio are independently associated with MetS in euthyroid middle-aged subjects. Longitudinal studies are needed to define this association and its potential health implications.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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