ECE2015 Eposter Presentations Thyroid cancer (90 abstracts)
Proprotein convertase subtilisin/kexin type 9 (PCSK9), soluble lectin-like oxidized ldl receptor 1 (SLOX-1) and ankle brachial index in short term overt hypothyroidism
Cigdem Ozkan 1 , Mujde Akturk 1 , Alev Eroglu Altinova 1 , Ethem Turgay Cerit 1 , Ozlem Gulbahar 2 , Mehmet Muhittin Yalcin 1 , Nuri Cakir 1 & Fusun Balos Toruner 1
1Department of Endocrinology and Metabolism, Faculty of Medicine, Gazi University, Ankara, Turkey; 2Department of Biochemistry, Faculty of Medicine, Gazi University, Ankara, Turkey.
Cardiovascular deleterious effects of short term hypothyroidism are not well known. We aimed to investigate proprotein convertase subtilisin/kexin type 9 (PCSK9), soluble lectin-like oxidized LDL receptor 1 (sLOX-1) and ankle brachial index (ABI) in patients with thyroid cancer with short term overt hypothyroidism due to thyroid hormone withdrawal (THW). Twenty-one patients who require radioactive iodine (RAI) ablation or RAI scan and thirty-six age, sex, BMI similar euthyroid healthy control subjects were enrolled into this study. Patients were evaluated both in subclinical thyrotoxic period when they were on suppressive levothyroxine therapy and overt hypothyroidism period due to THW for four weeks. Serum PCSK9, sLOX-1, lipid levels and ABI were measured in patient and control groups.Total cholesterol, LDL cholesterol, triglycerides and Apo B levels were increased in short term overt hypothyroidism compared to control group (P<0.001). Patients with short term overt hypothyroidism had significantly increased PCSK9 levels compared to control group (P<0.001). PCSK9 levels were also found to be increased before THW when compared to control group (P=0.004). sLOX-1 levels were not different between patients with short term overt hypothyroidism and control group (P=0.27). ABI was found to be significantly decreased in patients with short term overt hypothyroidism compared to control group (P=0.02). In conclusion, we found increased PCSK9 and decreased ABI which may contribute to the undesirable metabolic and vascular changes in thyroid cancer patients with short term overt hypothyroidism due to THW.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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