ECE2015 Eposter Presentations Thyroid cancer (90 abstracts)
Papillary thyroid carcinoma in children: 33 years of experience of a single institution in Serbia
Marko Buta 1 , Ivan Markovic 1, , Milovan Matovic 3, , Nada Santrac 1 , Igor Djurisic 1 , Zorka Milovanovic 5 , Gordana Pupic 5 & Radan Dzodic 1,
1Surgical Oncology Clinic, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia; 2Medical School, University of Belgrade, Belgrade, Serbia; 3Department of Nuclear Medicine, Clinical Center of Kragujevac, Kragujevac, Serbia; 4Medical School, University of Kragujevac, Kragujevac, Serbia; 5Department of Pathology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
Background: Well-differentiated thyroid carcinoma in children is rare but it shows aggressive behaviour. Gross lymph node metastases and distant metastases are common on first clinical presentation.
Patients and methods: During 33 years (1981–2014) at the Institute of Oncology and Radiology of Serbia 24 children were operated due to papillary thyroid carcinoma. Mean age was 12.6 (range 7–16) years. At the time of diagnosis 12.5% patients had lung metastases. Total thyroidectomy or completion of thyroidectomy was performed in all cases followed with central neck dissection and frozen section examination of the jugulo-carotid compartments. Median follow-up was 10.1 (range 2.0–29.4) years.
Results: pT1a tumours were found in 12.5%, pT1b in 25%, pT2 in 20.83%, pT3 in 25%, and pT4 in 16.67%. All patients had papillary thyroid carcinoma. Multifocal tumours were found in 79.17% and capsular invasion in 83.33%. Lymphonodal metastases in either central or lateral neck compartments were found in 75% of patients. Median DFI has not been reached and overall survival rate was 100%.
Conclusion: Papillary thyroid carcinoma in children is characterised with high rate of loco-regional aggressiveness, multifocality, capsular invasion, lymph node metastases, and distant metastases at the time of diagnosis. Extensive surgical approach should be performed in both primary and recurrent disease in young patients with well-differentiated thyroid carcinoma in order to achieve loco-regional disease control and long disease free survival.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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