Endocrine Abstracts

Introduction: The growth failure constant in turner syndrome is responsible for a spontaneous reduction in adult height with an average of 143 cm. Treatment with growth hormone has enhanced the stature prognosis.

Aim: Studying the final size of turner patients who have completed their growth.

Population, methodology: 40 patients became adult patients were assessed on linear growth. The following factors were studied: The age and size at diagnosis, the introduction of treatment with GHr and the final size.

Results: The mean age at diagnosis was 8.9±0.4 years, 45% over 10 years. The size at diagnosis was −4 DS/M and −3DS/TC. The age at initiation of treatment was 10±0.1 years with a mean treatment duration of 5±0.1 years. Ten patients were not able to be processed. Final height was −3, 5 DS/M and −2.5 S.D./TC with an average of 144±0.2 cm for patients treated and −4DS/M and −4 DS/TC for the others.

Discussion and conclusion: Unfavourable results in our patients are explained by delayed diagnosis. Treatment may not be éfficace if the GHr treatment is not given precociously patient inflammatoirs background processes, and infiltrating tumour of the pituitary stalk are rare. They are a heterogeneous group of lesions responsible of partial hypopituitarism or global objective. Search for of thickening of the pituitary stalk aetiologies and specify the clinical aspects.