ECE2015 Eposter Presentations Reproduction, endocrine disruptors and signalling (92 abstracts)
Characteristics of body composition in different phenotypes of women with polycystic ovary syndrome
Dusan Ilic 1 , Djuro Macut 1 , Ivana Bozic Antic 1 , Jelica Bjekic Macut 2 , Danijela Vojnovic Milutinovic 3 , Bojana Popovic 1 , Tamara Bogavac 1 , Biljana Kastratovic Kotlica 4 , Tatjana Isailovic 1 , Valentina Elezovic 1 & Sanja Ognjanovic 1
1Clinic of Endocrinology, Diabetes and Metabolic Diseases and Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 2CHC Bezanijska kosa, Belgrade, Serbia; 3IBISS, Belgrade, Serbia; 4Clinic of Gynecology and Obstetrics, and Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Obesity is closely associated with PCOS and worsens its metabolic and reproductive characteristics. The aim of this study was to evaluate body composition in different PCOS phenotypes. We evaluated 365 PCOS women (PCOS: 25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (Controls: 25.41±5.16 kg/m2; 30.35±5.62 years). PCOS were analyzed through four phenotypes: a (anovulation (ANOV), hyperandrogenism (HA), polycystic ovary morphology (PCOM)), B (ANOV, HA), C (HA, PCOM) and D (ANOV, PCOM). In all subjects body composition was evaluated using bioelectrical impedance (Tanita). We analyzed basal metabolic rate (BMR), whole body fat mass (WBFM), whole body fat free mass (WBFFM), total body water (TBW), abdominal fat mass (AFM), abdominal fat free mass (AFFM), legs fat mass (LFM). Ratio upper body (arms+abdomen)/legs fat mass was calculated.
BMI of phenotypes were: A: 25.11±6.36, B: 27.03±6.96, C: 25.63±5.84, D: 21.41±3.93 kg/m2. PCOS in comparison to controls had higher WBFM (24.42±13.50 vs 18.19±11.75 kg, P<0.001), AFM (12.17±7.68 vs 8.84±6.59 kg, P=0.002), LFM (4.50±2.03 vs 3.84±2.04 kg, P=0.006) and ratio upper body/legs fat mass (2.80±0.82 vs 2.39±0.75, P=0.007). There were no differences in BMR, WBFFM, TBW, AFFM between whole PCOS group and Controls. Phenotype D had lower BMI, WBFM, AFM and higher LFM than all other phenotypes (P<0.005). Phenotypes B and C had higher BMR, TBW and AFFM than phenotypes A and D and higher ratio upper body (arms+abdomen)/LFM than phenotype D (P<0.005). Phenotype B had higher WBFM and LFM than phenotype A (P<0.005). Our results demonstrated that body composition could relate to the androgenic status. Accordingly, phenotype B expressed the most altered body composition structure.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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