Endocrine Abstracts

It is well known that type 2 diabetes causes the endothelial dysfunction. However, insufficient attention is paid to the role of androgen deficiency in the formation of the early signs of endothelial dysfunction. The aim of the work was to evaluate the relationship between testosterone deficiency and markers of endothelial dysfunction in men with type 2 diabetes.

Materials and methods: Were examined 88 men aged 40–65 years with type 2 diabetes. All patients were divided into two groups matched for age. The first group included 47 patients with normotestosteronemy, the second – 41 men with testosterone concentration below 12 nM/l. Statistical analysis was performed using analysis of the median (Me [UQ; LQ] and comparison of two independent groups (U - Mann Whitney).

Results and discussion: We didn’t found statistically significant difference between the two groups in a concentration of E-selectin, P-selectin and VCAM-1. In the second group was found a significant increase of resistin (P=0.01): 5.81 (5.05; 8.7) ng/ml at the interval of values (2.98–18.52) vs 4.82 (3.63; 6.34) ng/ml (0.97–13.27) and ICAM-1 (P=0.04): 512.45 (350.1; 644.4) ng/ml vs 361.15 (256,8; 478.5) ng/ml. In addition, was observed an increase in CRP levels in patients with late onset hypogonadism compared to eugonadal men (12.65 (10.9, 14.00) vs 6.62 (2.59; 8.61) mg/l) (P=0.0001).

Summary: Hypotestosteronemy in patients with type 2 diabetes increases the concentrations of markers of endothelial dysfunction and CRP level which leads to raise of cardiovascular risk in these patients. Research of resistin and ICAM-1 concentrations in patients with type 2 diabetes and androgen deficiency reveals endothelial dysfunction at the early stage.

Supported by: Russian Science Foundation, No. 14-25-00052.

Disclosure: Supported by: Russian Science Foundation, № 14-25-00052.