ECE2015 Eposter Presentations Reproduction, endocrine disruptors and signalling (92 abstracts)
Clinical significance of ADAMTS1, ADAMTS5, ADAMTS9 aggrecanases and IL17, IL23, IL33 cytokines in polycystic ovary syndrome
Melia Karakose 1 , Kadir Demircan 2 , Esra Tutal 1 , Taner Demirci 1 , Muyesser Sayki Arslan 1 , Mustafa Sahin 3 , Huseyin Tugrul Celik 4 , Fatmanur Kazanci 4 , Erman Cakal 1 & Tuncay Delibasi 1,
1Department of Endocrinology and Metabolism, Diskapi Teaching and Research Hospital, Ankara, Turkey; 2Department of Medical Biology, Turgut Ozal University School of Medicine, Ankara, Turkey; 3Department of Endocrinology and Metabolism, Ankara University School of Medicine, Ankara, Turkey; 4Department of Biochemistry, Turgut Ozal University School of Medicine, Ankara, Turkey; 5Department of Internal Medicine, Hacettepe University School of Medicine, Kastamonu, Turkey.
Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) are involved in inflammation and fertility. The aim of this investigation was to evaluate to serum levels of ADAMTS1, ADAMTS5, ADAMTS9, IL17, IL23, IL33 and to find out the relationship between these inflammatory cytokines and ADAMTSs in PCOS patients.
Methods: Eighty patients with PCOS and 78 healthy female volunteers were recruited in the present study. Serum ADAMTS and IL levels were determined by a human ELISA in all subjects.
Results: The ADAMTS1 level was significantly lower and IL17A, IL23 levels were significantly higher in the PCOS patients compared to the controls (P<0.05). We could not find significant difference between the groups in terms of ADAMTS5, ADAMTS9, and IL33 levels. ADAMTS1 and ADAMTS9 had negative correlations with age, BMI, and waist/hip ratio. IL17A had positive correlation with total cholesterol and LDL.
Conclusion: The understanding of the molecular organization and function of ADAMTS in patients diagnosed with PCOS, which has an unknown pathogenesis, gains an importance and emerging hot topic. Based on the results of the present study, ADAMTSs and ILs might have key roles in PCOS pathogenesis. Further efforts are needed to establish causality for ADAMTS–IL axis.
Disclosure: This study has received financial support from TUBITAK (grant number 114S039, 2014).
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Endocrine Abstracts
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