Endocrine Abstracts

Currently actively studied the role of certain inflammatory and proinflammatory cytokines in the pathogenesis of insulin resistance, type 2 diabetes, obesity, atherosclerosis. However, the influence of testosterone deficiency on the balance of proinflammatory cytokines is unexplored. The aim of the work was to evaluate the influence of testosterone deficiency on metabolic parameters and levels of proinflammatory cytokines in patients with obesity and type 2 diabetes.

Materials and methods: We examined the 85 male patients, aged 40–65 years with obesity and type 2 diabetes, which were divided into two groups, matched for age. The first group included 44 patients with testosterone levels above 12.1 nM/l, the second – 41 men with content of hormone <12.1 nM/l.

Results and discussion: Analysis of the data shows a statistically more significant BMI in the group of hypogonadal patients (BMI 42.03±1.44 kg/m²), compared with eugonadal males (BMI 34.36±1.22 kg/m²). Also in the second group there were a statistically significant increases in the levels of serum total cholesterol (6.64±0.13 vs 5.79±0.16 mM/l) and triglycerides (2.31±0.31 vs 1.72±0.17 mM/l). In estimating the concentration of TNF-a in the serum was found that its level in patients with deficiency of testosterone (6.32±0.49 pg/ml) was significantly higher (P≤0.05) that those without hypogonadism (4.38±0.37 pg/ml). The results of the study of IL-6 showed a statistically significant increase in its content in the serum of patients with hypogonadism (5.39±0.89 pg/ml) compared with patients with normal levels of testosterone (3.78±0.36 pg/ml).

Conclusion: Reduced serum testosterone level is a factor contributing to manifestations of metabolic disorders and cytokine imbalance in patients with obesity and type 2 diabetes. Androgen deficiency may be regarded as an additional risk factor for cardiovascular disease and diabetes.

Disclosure: This work was supported by the Russian Science Foundation, grant No. 14-25-00052