Endocrine Abstracts

Introduction: The aim of this study, left ventricular systolic and diastolic function by echocardiography and tissue Doppler echocardiographic evaluation and relationship serum N-terminal pro-B-type brain natriuretic peptide (NT-proBNP) levels of women with polycystic ovary syndrome (PCOS).

Materials and method: Thirty-two women with PCOS (age: 23.4–4.6 years; BMI: 23.8–4.8 kg/m²), similar age and BMI have features 30 healthy womens controls involved in the study. Anthropometric features, NT-proBNP levels, HOMA-IR index, renal and hepatic function parameters, serum lipid and cholesterol levels, hormonal tests were measured. Interventricular septum was evaluated by tissue Doppler echocardiography. Statistical Package for the Social Sciences (SPSS) 17 programme was used in the statistical analysis of data. Student’s t-test, Pearson’s correlation test, and multiple regression analyse test results of all the parameters stuided in the PCOS and control group. İmportance level of values whose P value <0.05 is taken as statiscally significantly.

Results: PCOS group had NT-proBNP (P=0.04), total testosterone (P=0.005), cholesterol (P=0.02), and triglycerides (P=0.006) levels higher than control group. Echocardiographic assessment of the interventricular septum thicknes and width of the aortic root measurements levels in the PCOS group higher than the control group. Also, left ventricular mitral valve E-wave velocity (P=0.039) in the PCOS group were significantly less than the control group and left ventricular deseleration time (P=0.035) longer than control group. PCOS group with multiple regression analysis when the high NT-proBNP levels was positively correlated with age (r=0.364, P=0.002), interventricular septum thicknes (İVST) (r=0.299, P=0.02), and width of aortic root (r=0.272, P=0.025).

Conclusions: Our study results have shown that, NT-proBNP levels have able to a biochemical cardiac early marker of diagnosis subclinical diastolic dysfunction in younger women with PCOS. Early time examined by conventional echocardiography and tissue Doppler echocardiography possibly to helpful determinate early diastolic dysfunction of women with PCOS.