ECE2015 Eposter Presentations Pituitary: clinical (121 abstracts)
Analysis of the aetiology of hypopituitarism: the results from double centre study
Mustafa Caliskan 1 , Mehtap Navdar Basaran 2 , Selvihan Beysel 1 , Muyesser Sayki Arslan 1 , Bekir Ucan 1 , Mazhar Muslum Tuna 2 , Erman Cakal 1 , Dilek Sensoz Berker 2 , Serdar Güler 2, & Tuncay Delibasi 1,
1Department of Endocrinology and Metabolism, Diskapi, Teaching and Research Hospital, Ankara, Turkey; 2Department of Endocrinology and Metabolism, Numune Teaching and Research Hospital, Ankara, Turkey; 3Faculty of Medicine, Hitit University, Corum, Turkey; 4School of Medicine (Kastamonu), Hacettepe University, Ankara, Turkey.
Introduction: Hypopituitarism is commonly acquired in adult life and its main causes are pituitary tumors and/or their treatments, empty sella syndrome and etc.
Patients and methods: A double centre, cross-sectional database study was performed in Turkish population for last 10 years to investigate the etiology of hypopituitarism. One-hundred forty nine patients were included (53% female and 47% male) with a mean age of 47.9±15.6 years (ranging from 19 to 83 years). Patients were classified by the causes of hypopituitarism as pituitary tumors (due to direct effect of the pituitary tumors and/or their treatments), extra-pituitary tumors, and non-tumoural causes.
Results: It was found that the most common etiology of pituitary dysfunction was due to non-tumoural causes (48.9%) among all patients (Table 1). According to the subgroup analysis of the causes of hypopituitarism, the most common cases with more than 10% frequencies were prolactinomas, non-secretory adenomas, idiopathic, and empty sella (Table 1). In terms of the type of hormonal deficiencies, FSH/LH deficiencies was the most common hormonal deficit (93.9%). In 70.4% of the patients, four anterior pituitary hormone deficiencies (FSH/LH, ACTH, TSH and GH) were present.
| Aetiology | n (%) |
| Pituitary adenomas | 62 (41.6%) |
| Prolactinomas | 13 (8.7%) |
| Acromegaly | 2 (1.3%) |
| Cushing | 3 (2%) |
| Gonadotrophinomas | 1 (0.7%) |
| Thyrotropinomas | 1 (0.7%) |
| Non-secretory adenomas | 42 (28.2%) |
| Extra-pituitary tumors | 13 (8.7%) |
| Non-tumoural causes | |
| Idiopathic | 13 (8.7%) |
| Sheehan’s syndrome | 59 (39.6%) |
| Apoplexia | 2 (1.3%) |
| Total | n=149 |
| Note: Frequencies over 10% were represented in bold. | |
Conclusion: Although non-secretory pituitary adenomas were the most common cause of hypopituitarism in male patients, Sheehan’s syndrome was the leading cause of hypopituitarism in female patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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