ECE2015 Eposter Presentations Pituitary: clinical (121 abstracts)
Outstanding growth response to GH replacement therapy in three different cases of GH deficiency
Ljiljana Saranac 1 , Zlatko Djuric 1 , Ivana Markovic 2 , Hristina Stamenkovic 1 & Dragoljub Lazarevic 1
1Pediatric Clinic, Faculty of Medicine Nis, University of Nis, Nis, Serbia; 2Institute of Radiology, University Clinical Centre Nis, Nis, Serbia.
Introduction: Growth response in GH deficient children during GH replacement therapy rarely fulfil our projections and patient’s expectations. We here report three cases with outstanding growth response.
Case reports: First patient was diagnosed as gluten enteropathy in early childhood, but the diet didn’t improve his growth. At age of 7 years the diagnosis of isolated GH deficiency (GHD) was established and GH substitution therapy introduced. Next 2 years his growth velocity increased to 10 cm/year. Routine head MRI revealed hypothalamic tumour. Severe growth failure in 8-years-old boy with history of purulent meningitis in toddler period and head trauma at age of 6. MRI discovered congenital pituitary abnormality (pituitary hypoplasia and ectopic posterior pituitary). Combined substitution therapy improved his height from −3S.D. to +0.67S.D. An empty sella syndrome was diagnosed in short obese boy with delayed puberty. At diagnosis his height of 148.8 cm was −1.88S.D. (P3). During 4 years of combined therapy he achieved height of 184 cm (P90), +1.28S.D.
Conclusion: Mechanisms of excellent growth response in these GH deficient children certainly include concomitant hypogonadism, but somatostatin deficiency may also be considered.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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