Endocrine Abstracts

Introduction: The effects of sex steroids on lymphocytes count and functions are well known and it is propounded that autoimmune diseases more common in women. NLO index is an indicator of inflammative situation. In this study, it has been aimed that neutrophil/lymphocytes ratio (NLO) calculation by determining neutrophil/lymphocytes values in patients who diagnosed as hypogonadotropic hypogodanism and searching that whether there is significant difference between healthy group or not.

Method: 33 patients who have been diagnosed as hypogonadotropic hypogodanism, 56 people who have no statistically significant difference in point of age, BMI among them and they are completely healthy people as a control group, totally 89 people have been incorporated to the study. It has been calculated that patient group’s age average is 22.4±7.4 and control group’s age average is 23.1±6.4. Statistically significant difference couldn’t be determined among them (P=0.6). Patients’ neutrophile and lymphocytes values have been evaluated by studying. Patients’ C-reactive protein(CRP) and testosterone levels have been registered again by studying.

Results: In the study results; patient group NLO has been founded as 1.8±1.3 and healthy group NLO has been founded as 1.4±0.3 and statistically significant difference has been determined among them (P=0.03). Statistically significant difference has been respectively determined between patient group and healthy group in point of white blood cell count (7.9±3.1 and 6.7±1.1, P.0.04), neutrophil (4.6±2.7 ve 3.7±0.7, P=0.03), lymphocytes (2.4±0.6 and 2.7±0.7, P=0.04) and CRP(2.0±1.3 and 0.9±1.0, P=0.01).In the group which has hypogonadotropic hypogodanism; while positive correlation is being determined between NLO (r=0.228, P=0.03), white blood cell (r=0.564, P<0.001) and neutrophil (r=0.847, P<0.0001), negative correlation has been determined between testosterone and lymphocytes count (r=−0395, P=0.001).

Discussion: We can say that sex steroids can be effective on lymphocytes and neutrophil count depending on the results from this study. Whether to return to normal of sex steroids replacement with these functions must be demonstrated by more detailed studies.