ECE2015 Eposter Presentations Pituitary: clinical (121 abstracts)
Evaluation of GH secretion after stroke
Orsolya Nemes 1 , Zita Tarjanyi 1 , Laszlo Szapary 2 , Beata Ruzsa 1 , Beata Bodis 1 , Laszlo Bajnok 1 & Emese Mezosi 1
11st Department of Internal Medicine, University of Pecs, Pecs, Hungary; 2Department of Neurology, University of Pecs, Pecs, Hungary.
Objective: According to recent studies, impaired secretion of GH is a frequent finding after ischaemic stroke. The aim of our study was to compare various available GH stimulation tests in post-stroke patients.
Design: Seventeen patients were included in the study (12 males; mean age: 60.5 years; mean BMI, 27.7 kg/m2) with a mean 19.6 (±7.3) months after stroke. For screening, glucagon and small dose (0.15 μg/kg) GHRH-arginine (sdGHRH-A) stimulation tests were carried out in consecutive days. If either or both of them were abnormal, a large dose (1 μg/kg) GHRH-arginine (ldGHRH-A) stimulation, as a standard confirmatory test was carried out, as well.
Results: Maximum GH values reached in sdGHRH-A and glucagon stimulation tests were strongly correlated to each other (r=0.943; P<0.001), but neither showed association with ldGHRH-A results. Furthermore, IGF-I levels did not correlate with stimulated peak GH values received in any of the three tests. Comparing diagnostic interpretations of stimulation tests to each other, considerable discrepancies were detected in all directions, partly due to various cut-off values of the applicable criteria.
Conclusions: Abnormal GH secretion is common after stroke. If this indication were being included in the screening for GH insufficiency, a larger trial is warranted to evaluate which tests are appropriate because a single GH stimulation test may not necessarily be enough in this population.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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