Endocrine Abstracts

Purpose: To evaluate the effectiveness of a combined antihypertensive therapy in treating arterial hypertension (AH) in patients suffering from diabetes mellitus (Type 2 DM) on different stages of obesity.

Materials and methods: 80 patients suffering from Type 2 DM and AH on different stages of obesity underwent a monitoring. Depending on the stage of obesity, the patients were divided into three groups. The groups were comparable by age, sex, AH stage. The patients received comparable oral hypoglycemic agents. On voluntary basis the patients did not receive antihypertensive agents 5–7 days before being included into the research. Aiming at correcting AH, the patients received PRESTANCE (the combination of perindopril and amlodipine) in the doses of: 5/5, 5/10,10/5,10/10 during 12 months. Daily monitoring of AP (ABPM) was conducted with the help of a non-invasive portable system, HbA1c was determined. The blood glucose was determined on an empty stomach and 2 h after meals. The treatment of results was carried out with the use of STATISTICA pack.

Results: The average age of the patients was 57.5±3.4 years, women prevailed – 75%. The average ABP value was: 168±11 and 105±7 mmHg – for systolic and diastolic blood pressure respectively. By week 12 observations of 85% patients from group 1 reached the target ABP and was retained until week 48, 78% patients from group 2 reached the target values of ABP and 72% patients from group 3 retaining it until observation week 48. By week 12 of observation in each group was significantly (P<0.01) decreased the level of total cholesterol plasma, LDL cholesterol, triglycerides, fasting and postprandial blood glucose, HbA1c and BMI showed a decrease. All the patients participating in the research, showed good tolerance of PRESTANCE.

Conclusions: The combination of perindopril and amlodipine provides sustainable management of ABP in patients with Type 2 DM and different obesity stages, is well tolerated, has a beneficial effect on carbohydrate and lipid metabolism, leads to weight decrease.