Endocrine Abstracts

Introduction: Metabolic syndrome (MetS) is characterised by a combination of visceral obesity, hypertension, insulin resistance, dyslipidemia, and impaired glucose tolerance. It is a prominent risk factor for cardiovascular morbidity and mortality. The etiology of MetS is complex. The progression of MetS is influenced by genetic susceptibility and environmental factors. The aim of this study was to investigate a possible association between transient receptor potential (TRP) channels gene polymorphisms and MetS in a Turkish population.

Methods: A total of 142 patients with obesity-related MetS and 166 healthy controls with similar age and sex were enrolled to this study. Genomic DNA from the participants was analyzed by a BioMark 96.96 dynamic array system (Fluidigm, South San Francisco, CA, USA). For calculation of the significance of differences in genotype and allele frequencies, the χ² test or Fisher’s exact test was used. A P value of <0.002 (0.05/25) was considered statistically significant after Bonferroni’s correction for multiple testing.

Results: There was an increase in A allele (64.6% in patients vs 49.5% in controls) and decrease in G allele frequencies (35.4% in patients vs 50.5% in control, P=0.0019) of the TRPM5 gene rs4929982 (Arg578Gln) polymorphism. We also observed that the distribution of genotype and allele frequencies of the TRPM8 gene rs12472151 in MetS patients were significantly different from controls (P<0.0001). However, no associations were found with the other 23 polymorphisms studied.

Conclusion: In conclusion, to the best of our knowledge, the present case–control study is the first to examine the potential involvement of TRP channel gene variations in the risk of incident MetS. Our data showed that genetic polymorphisms in TRPM5 and TRPM8 genes may modify individual susceptibility to MetS in the Turkish population.

Disclosure: This study was supported by a project (TF.13.20) from the University of Gaziantep.