ECE2015 Eposter Presentations Obesity and cardiovascular endocrinology (108 abstracts)
Neutrophil to lymphocyte ratio as an inflammatory marker in obesity
Neslihan Soysal-Atile 1 , Betül Ekiz-Bilir 1 , Bülent Bilir 2 , Derya Baykiz 3 , Birol Topçu 4 & Murat Aydin 5
1Endocrinology Department, Tekirdag State Hospital, Tekirdag, Turkey; 2Internal Medicine Department, Namik Kemal University Faculty of Medicine, Tekirdag, Turkey; 3Cardiology Department, Tekirdag State Hospital, Tekirdag, Turkey; 4Biostatistics Department, Namik Kemal University Faculty of Medicine, Tekirdag, Turkey; 5Biochemistry Department, Namik Kemal University Faculty of Medicine, Tekirdag, Turkey.
Aim: Cardiovascular morbidity and mortality of obesity is associated with classic risk factors, namely dyslipidaemia, hypertension and impaired glucose metabolism. Aim of this study is to evaluate inflammation as an independent risk factor by using neutrophil to lymphocyte ratio (NLR).
Materials and methods: Patients who admitted to our outpatient clinic between January and December 2014 were assessed retrospectively. Patients diagnosed as diabetes, prediabetes, hypertension, thyroid dysfunction and any acute or chronic inflammatory disorder were excluded. A total of 437 female cases were included in the study. Cases were grouped according to BMI.
Results: Groups were age-matched (P=0.513). HOMA-IR and trigliseride values were positively, HDL levels were negatively correlated with BMI (P<0.05). There was no association between LDL values and BMI. There was no statistically significant difference between NLR values of groups 0, 1, 2 and 3. A trend toward higher NLR in group 4 was observed but the difference did not reach statistical significance (P=0.117). Group 5 however had significantly higher NLR values (P=0.000)
| Group (BMI kg/m2) | n | HOMA-IR | Trigliseride | HDL | LDL | NLR |
| 0 (18.0–24.9) | 45 | 1.33±0.63 | 90.67±47.71 | 58.79±15.43 | 123.48±50.51 | 1.85±0.68 |
| 1 (25.0–29.9) | 86 | 1.93±0.89 | 106.42±62.13 | 53.30±14.85 | 133.31±39.83 | 1.86±0.53 |
| 2 (30.0–34.9) | 98 | 2.43±1.29 | 126.00±59.38 | 46.93±11.89 | 135.40±33.55 | 1.75±0.63 |
| 3 (35.0–39.9) | 76 | 2.80±1.50 | 147.10±75.07 | 48.48±15.20 | 131.03±36.28 | 1.79±0.56 |
| 4 (40.0–44.9) | 67 | 3.87±2.26 | 152.17±70.21 | 46.64±21.46 | 130.19±32.46 | 2.28±0.53 |
| 5 (>45) | 65 | 3.98±1.45 | 144.85±82.09 | 44.98±11.12 | 126.94±34.59 | 3.07±2.23 |
Conclusion: Increased NLR value is considered as an inflammatory marker and an indicator of cardiovascular risk. Our results established higher NLR values in morbid obesity patients and emphasised the increased cardiovascular risk in morbid obesity.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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