Endocrine Abstracts

Introduction: Oxidative stress is one of the possible mechanisms involved in the pathogenesis of the obesity-related metabolic complication. In this study, we aimed to investigate effect of weight loss with bariatric surgery on IMA, high sensitive C-reactive protein (hs-CRP), serum total antioxidant status (TAS), total oxidant status (TOS) levels.

Materials and methods: In this prospective study, plasma IMA, hs-CRP, TAS and TOS levels were measured before and 6 months after laparoscopic sleeve gastrectomy in 60 morbidly obese patients with a BMI of 46.6±6.7 kg/m². 43 age-matched healthy subjects with a BMI of 24.6±3 recruited as controls. Metabolic parameters including serum levels of fasting glucose, HbA1c, homeostatic model assessment of insulin resistance (HOMA-IR), C-peptide, LDL, HDL, triglyceride were also measured before and after surgery.

Results: Excess weight loss (EWL) and percentage of EWL were 34.9±10.5 kg and 27.8% in obese patients. Plasma IMA levels before surgery was significantly increased in patients compared to controls (P<0.05). We found significantly increased hs-CRP levels in patients compared to controls (P<0.001). Plasma IMA and hs-CRP levels were significantly decreased in patients after 6 month of bariatric surgery (P<0.05 and P<0.001, respectively). At 6th month of surgery, BMI of patients was still significantly higher than controls (P<0.01), hs-CRP levels were significantly increased in patients (P<0.001) but there was no significant difference in IMA levels. A statistically significant reduction was found in the TOS values after the surgery (P<0.001), but there were no significant changes in the TAS levels. Significantly decreased levels of fasting glucose (P<0.01), HbA1c (P<0.001), HOMA-IR (P<0.01), C-peptide (P<0.001), LDL-C (P<0.001) and triglyceride (P<0.001) and increased levels of HDL-C (P<0.001) were observed after bariatric surgery.

Conclusion: Our findings supported that weight loss with bariatric surgery improves IMA, hs-CRP, TOS levels and metabolic profile in patients. Along with still higher BMI in patients after surgery, no significant difference in IMA levels between obese and healthy group suggested that bariatric surgery could have beneficial effects on oxidative stress beyond weight loss.

Disclosure: This work was supported by Bezmialem Research Council (grant number 12.2013/25).