ECE2015 Eposter Presentations Diabetes (pathiophysiology & epitemiology) (80 abstracts)
Association of neutrophil to lymphocyte ratio with different glucose metabolism status
Betül Ekiz Bilir 1 , Neslihan Soysal Atile 1 , Bülent Bilir 2 , Birol Topçu 3 , Sonat Pınar Kara 2 , Derya Baykiz 4 & Murat Aydin 5
1Tekirdag State Hospital, Tekirdag, Turkey; 2Internal Medicine Department, Namik Kemal University, Tekirdag, Turkey; 3Biostatistics Department, Namik Kemal University, Tekirdag, Turkey; 4Cardiology Department, Tekirdag State Hospital, Tekirdag, Turkey; 5Biochemistry Department, Namik Kemal University, Tekirdag, Turkey.
Introduction: Several studies have shown that prediabetic patients had increased concentrations of inflammatory markers and this association is independent of underlying obesity. Netrophil to lymphocyte ratio (NLR) is considered as a new inflammatory marker and has been studied extensively in a variety of clinical conditions especially in solid tumours and cardiovascular diseases. Studies evaluating the subclinical inflammation in prediabetes revealed positive association of some inflammatory markers with hyperglycaemia. The aim of this study is to evaluate the association of NLR with different glucose metabolism status groups.
Methods/design: The study included 259 patients (213 females, 46 males; mean age 47.4±11.5 and 48.8±15.7 respectively) who admitted to an Out-Patient Endocrinology Clinic of a State Hospital in Turkey. The asymptomatic adults were classified in three groups as normal glucose metabolism, impaired fasting glucose, and impaired glucose tolerance according to 75 g-oral glucose tolerance test. The patients who had diabetes, any thyroid dysfunction, malignancy, pregnancy, any acute or chronic infectious or inflammatory disease, or patients who were on oral anti-diabetic drugs were excluded from the study. BMIs of patients, serum fasting glucose and insulin levels, lipid parameters and complete blood counts with differentials were registered.
Results: There were statistically significant differences between groups in terms of fasting glucose and HOMA-IR levels as expected (P=0.000 and P=0.047 respectively). Otherwise there are no differences in terms of BMI, insulin, lipids, and NLR.
| Groups | Age | BMI | Glucose | Insulin | HOMA-IR | TG | HDL | LDL | NLR |
| Normal (n=53) | 42.2±13.9 | 34.7±7.1 | 93.9±7.3 | 11.6±6.9 | 2.7±1.6 | 152±97 | 48±14 | 136±31 | 1.86±0.67 |
| IFG (n=120) | 48.7±11.1 | 34.6±7 | 106.8±7 | 12.9±6.5 | 3.4±1.7 | 160±90 | 44±13 | 138±39 | 1.8±0.61 |
| IGT (n=86) | 49.5±12.3 | 35.9±8 | 107.6±8.1 | 13.7±7.3 | 3.7±2.1 | 178±106 | 45±12 | 133±36 | 1.85±0.76 |
Conclusion: Glucose metabolism status was not associated with NLR in our small study cohort. Studies based on a wider population might give a different result in this manner.
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Endocrine Abstracts
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