ECE2015 Eposter Presentations Diabetes (pathiophysiology & epitemiology) (80 abstracts)
Risks of having gestational diabetes in the future for mothers and their offspring
Sabin Goktas Aydin 4 , Ayse Kubat Uzum 1 , Banu Kucukemre Aydin 2 , Sevda Ozel Yildiz 3 , Selda Gedik 1 , Cemile Idiz 1 , Bülent Canbaz 1 , Firdevs Bas 2 , Ruveyde Bundak 2 & Nevin Dinccag 1
1Endocrinology and Metabolism Division, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; 2Paediatric Endocrinology and Metabolism Division, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; 3Biostatistics Department, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; 4Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Introduction: Gestational diabetes (GDM) has an important short and long-term health consequences for both the mother and her offspring. The aim of this study was to evaluate current metabolic status of women with GDM history and their offspring approximately at 10th year after delivery.
Methods: 24 mothers who had GDM 10 years before (mean age 41.08±4.13 years and BMI 30.3±5.9) and their children (11 females, 13 males; mean age of 11.0±1.9 years) were enrolled into the study. To evaluate current metabolic status of mothers, 75 g OGTT was performed and according to ADA criteria they were classified into two groups as normal glucose tolerance (group 1: NGT) and glucose intolerance (group 2: IGT and/or DM). Outcomes of foetal determinants were recorded and current clinical status and laboratory features of offspring were checked and evaluated if there would be any associations with mothers’ metabolic status.
Results: 41.6% of mothers had any degree of glucose intolerance at 10th year after delivery. As we concluded foetal determinants in groups, measurements of birth weight (g), length (cm) were found as 3625.6±680 vs 3197.6±608; 147.6±11.5 vs 146.7±13.0 respectively. As we considered daily status of children, their BMI and waist circumferences were observed as 18.4±3.1 kg/m2 vs 20.6±5.7 kg/m2 and 67.7±12.2 cm vs 71.9±10.1 cm respectively (P>0.05). Although the difference was not significant, waist circumference and central obesity of offspring in group 2 was found higher. Also results of fasting glucose and insulin levels of children in group 2 were higher than the others; but difference was not statistically significant. Five of them had lipid profile changes.
Conclusion: Frequency of glucose intolerance may be increased in the follow-up years; offspring of mothers having prediabetes may have great risk for obesity and insulin resistance in the future; especially at pubertal period. Those adolescents should be identified and efforts should be done to prevent development of metabolic syndrome and lifestyle should be planned to preserve beta cell function of the pancreas before puberty.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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