ECE2015 Eposter Presentations Diabetes (pathiophysiology & epitemiology) (80 abstracts)
Serum irisin level increases throughout the gestational period and it does not play role in development of gestational diabetes mellitus
Seda Seda 1 , Hasan Aydın 2 , Mehmet Sargın 3 , Asuman Orçun 4 , Ali Özdemir 5 , Ayhan Çelik 6 & Gülgün Aslan 7
1Division of Endocrinology and Metabolism, Fatih Sultan Mehmet Training and Educational Hospital, Istanbul, Turkey; 2Division of Endocrinology and Metabolism, Yeditepe University Hospital, Istanbul, Turkey; 3Diabetes Department, Kartal Lutfi Kirdar Training and Educational Hospital, Istanbul, Turkey; 4Division of Biochemistry, Kartal Lutfi Kirdar Training and Educational Hospital, Istanbul, Turkey; 5Department of Internal Medicine, Fatih Sultan Mehmet Training and Educational Hospital, Istanbul, Turkey; 6Division of Obstetrics and Gynecology, Fatih Sultan Mehmet Training and Educational Hospital, Istanbul, Turkey; 7Department of Internal Medicine, Kartal Lutfi Kirdar Training and Educational Hospital, Istanbul, Turkey.
Objective: Irisin is a novel adipomyokine that regulates the differentiation and phenotype of adipose tissue. It induces an increase in total body energy expenditure, improves insulin sensitivity, and glucose tolerance. It showed that the levels of irisin are low in obese, diabetic and impaired glucose tolerance patients. However, the information of the levels of circulating irisin in gestational diabetes mellitus (GDM) is controversial. In this study, we investigated i) the levels of irisin over the first and third trimester of gestation and ii) the change of irisin between first and third trimesters in GDM subjects.
Material and methods: Serum irisin was measured by an ELISA in a longitudinal prospective cohort study in 220 women. There are 154 healthy pregnant and 66 GDM women.
Results: The levels of irisin were low in the first trimester, but higher in the third trimester (0.76±0.54 vs 1.32±0.76, P<0.0001). There was a significant negative correlation between age (P: 0.002, r: −0.207), BMI (P: 0.03, r: −0.188) and weight in the first trimester (P: 0.03, r: −0.185) and HbA1c in the first trimester (P: 0.0001, r: −0.374). There was not any correlation between any parameters and the levels of irisin in the third trimester. The levels of irisin in the first trimester are low but high in the third trimester in the patients with GDM (0.62±0.35 vs 1.26±0.86, P<0.0001). But the levels were not different between women with GDM and healthy controls.
Conclusions: The levels of irisin are low in the first trimester but high in the later stage in third trimester. There is no effect of irisin on the development of GDM. The physiological significance of these findings needs to be assessed in future experiments.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more