ECE2015 Eposter Presentations Diabetes (pathiophysiology & epitemiology) (80 abstracts)
Effects of H. pylori eradication on metabolism and body weight in obese and non-obese patients
M Mar Roca-Rodríguez 1 , Isabel Cornejo-Pareja 1 , Leticia Coín-Aragüez 2 , Juan Alcaide 2 , Carlos Clu-Fernández 1 , Laura Viñuela-González 3 , Elena Durán-Martín 3 , Laura Mora-Navas 3 , Isabel Mancha-Doblas 1 & Francisco J Tinahones 1,
1Department of Endocrinology and Nutrition, Virgen de la Victoria and Regional Hospitals, Malaga, Spain; 2Investigation Unit (IBIMA), Virgen de la Victoria Hospital, Malaga, Spain; 3Department of Microbiology, Virgen de la Victoria Hospital, Malaga, Spain.
Introduction: Many studies showed that H. pylori infection could be an independent predictor for insulin resistance and could regulate metabolism and body weight.
Aim: To evaluate changes in metabolism induced by an oral glucose tolerance test (OGTT) before and after antibiotic eradication treatment in patients colonized by H. pylori.
Materials and method: Prospective case-controlled study with a sample of patients colonized by H. pylori. In an intra-subject analysis, clinical data and levels of ghrelin and GLP1 were analysed at baseline and post-OGTT before and after antibiotic eradication treatment.
Results: We studied 32 patients (75% women and 21.9% obese). Average age was 49±11.5 and 46.9% had personal history of gastrointestinal disease. We found a significant decrease of HbA1c and 120 post OGTT glucose after treatment; and significant correlations between ghrelin with waist circumference and BMI (negative), and with glucose, insulin, HbA1c and LDL-Chol (positive). We also found significant positive correlations between GLP-1 and insulin, and between the difference in HbA1c and levels of GLP-1 post-treatment at all times after OGTT. No significant differences were found in obese patients before and after treatment, whereas non obese patients showed significant decrease in levels of 120 post OGTT glucose and HbA1c. Comparing non obese and obese patients, we found significant differences pre-treatment in fasting insulin and C-peptide; and post-treatment in diastolic blood pressure and C-reactive protein. 78.1% of patients completed correctly the treatment and 81.3% achieved the eradication of H. pylori.
Conclusions: Significant improvement in carbohydrate metabolism was observed after H. pylori eradication. No significant differences in body composition, blood pressure figures and levels of ghrelin and GLP-1 were found after treatment, but nearly significant decline in ghrelina. Significant correlations between plasma glucose and insulin with ghrelin and GLP-1 were found. More than 85% of patients achieve H. pylori eradication.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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