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Endocrine Abstracts (2015) 37 EP515 | DOI: 10.1530/endoabs.37.EP515

ECE2015 Eposter Presentations Diabetes (complications & therapy) (143 abstracts)

Roux-en-Y gastric bypass reduces proteinuria in diabetic kidney disease to a greater extent than weight loss alone in the Zucker diabetic fatty rat without a greater improvement in renal inflammation

Karl Neff 1 , Jessie Elliott 1 , Sabrina Jackson 1 , Kathrin Abegg 2, , Caroline Corteville 2, , Rodrigo Munoz 4 , Neil Docherty 1 , Thomas Lutz 2, & Carel le Roux 1

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1School of Medicine and Medical Sciences, Conway Institute, Diabetes Complications Research Centre, University College Dublin, Dublin, Ireland; 2Vetsuisse Faculty, Institute of Veterinary Physiology, University of Zurich, Zurich, Switzerland; 3Institute of Laboratory Animal Sciences, University of Zurich, Zurich, Switzerland; 4Department of Digestive Surgery, School of Medicine Santiago, Pontificia Universidad Católica, Santiago, Chile.

Background: The effect of Roux-en-Y gastric bypass (RYGB) on diabetic kidney disease (DKD) is unclear. We used a Zucker diabetic fatty rat (ZDF) model of DKD to determine the effect of RYGB on histopathological markers of DKD, proteinuria, and MCP1 excretion.

Methods: ZDF rats underwent RYGB (n=15) or sham surgery (n=14) at 18 weeks of age. Eight sham operated animals were food restricted to match the weight loss of the RYGB group (body-weight matched (BWM) group). Animals were sacrificed at age 31 weeks.

Results: Macrophage infiltration (ED1 staining), urinary MCP1:creatinine ratio and MCP1 expression was reduced by in both RYGB and BWM groups (P<0.05). Despite similar effects on inflammation, RYGB had a greater effect on reducing proteinuria (P=0.01).

Conclusions: Weight loss alone can remediate renal inflammation, but RYGB has a greater effect on proteinuria. This may be due to other mechanisms such as incretin effects.

Disclosure: This work was supported by Science Foundation Ireland ref 12/YI/B2480.

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Endocrine Abstracts
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