Endocrine Abstracts

Goal: To study occurrence frequency of diabetic foot syndrome (DFS) in three pilot regions of Uzbekistan.

Material and methods: Upon WDF project, ‘UMID’ Association of Tashkent and RRPMCE have screened T1DM and T2DM patients for DFS in three pilot regions (Andizhan, Tashkent, and Kashkadarya areas). 663 patients examined; of them 581 T2DM patients and 82 T1DM peoples in the 25–65 age groups with duration of the disease 5–15 years. Results of USI Doppler velocimetry, levels of glycaemia, HbA1c, cholesterol, HDL, LDL, and triglycerides were studied.

Results: 83.2% of T2DM and 67.4% of T1DM had diabetic polyneuropathy. Frequency of DFS occurrence was 55.3% (T2DM) and 31.7% (T1DM) accordingly. The greatest number of lower limb amputations (3.8%) and re-amputations (2.0%) was found in T2DM patients with disease of 7–10 years. Results of interviews pertaining to rules of foot care showed a poor knowledge on DFS prevention which explains a rise in a number of amputations in PDM in rural regions. 94.2% of PDM were in a decompensation stage (HbA1c >9.5%) irrespective of history of the disease. 68% of PDM were hypertensive. 36% of PDM (mostly T2DM patients with obesity grades 1 and 2) had high levels of cholesterol and LDL (5.6±0.7 and 4.01±0.12 mmol/l respectively) with low level of HDL (0.53±0.05 mmol/l) and level of triglycerides of 2.8±0.3 mmol/l.

Conclusions: i) Frequency of DFS occurrence in three pilot regions of Uzbekistan made 55.3% in T2DM patients and 31.7% in those of T1DM; ii) the greatest number of lower limb amputations (3.8%) and re-amputations (2.0%) was found in T2DM patients with duration of the disease 7–10 years; and iii) decompensation stage (HbA1c >9.5%) in 94.2% of PDM is one of principal causes of high frequency of DFS occurrence and a considerable number of amputations in PDM.

Disclosure: World Diabetes Foundation grant number 08-379, dd 07.09.2009.