Risk factors, aetiology, and prognosis in patients with ischaemic stroke and diabetes mellitus

Julia Silva-Fernandez; Rafael Garcia-Ruiz; Paloma Moreno-Moreno; Rosa M Garcia-Ruiz; Carolina Gonzalez-Pereira

doi:10.1530/endoabs.37.EP459

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Endocrine Abstracts (2015) 37 EP459 | DOI: 10.1530/endoabs.37.EP459

ECE2015 Eposter Presentations Diabetes (complications & therapy) (143 abstracts)

Risk factors, aetiology, and prognosis in patients with ischaemic stroke and diabetes mellitus

Julia Silva-Fernández ¹ , Rafael García-Ruiz ² , Paloma Moreno-Moreno ³ , Rosa M García-Ruiz ⁴ & Carolina González-Pereira ⁵

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¹Endocrinolgy Unit, Mancha Centro General Hospital, Alcázar de San Juan, Ciudad Real, Spain; ²Neurology Unit, Mancha Centro General Hospital, Alcázar de San Juan, Ciudad Real, Spain; ³Endocrinology Unit, Reina Sofia University Hospital, Córdoba, Spain; ⁴Pedreguer Primary Care Center, Pedreguer, Alicante, Spain; ⁵Intensive Care Unit, University Central Hospital of Asturias, Oviedo, Asturias, Spain.

Objective: To describe the clinical, aetiological and prognostic differences in diabetic and non-diabetic ischaemic stroke (IS) patients.

Materials and methods: Retrospective analysis of prospective series of IS patients. Patients were classified as non-DM and DM patients. Demographic and clinical characteristics were compared between two groups. IS prognosis was evaluated by modified Rankin scale (mRS) and NIHSS (NIH stroke scale).

Results: 138 were included (53 diabetic and 71 non-diabetic). Mean age was 73.95 (±14.43) years in DM patients and 74 (±11.51) in non-DM. The prevalence of hypertension (88.6% vs 66.9%, P<0.05), hypercholesterolemia (56.6% vs 33.8%, P<0.05), coronary artery disease (15% vs 8.4%, P 0.18), peripheral artery disease (3.7% vs 2.8%, P 0.76), previous stroke (33.9% vs 15.4%, P<0.05), and atrial fibrillation (16.9% vs 9.8%, P 0.24) was higher in DM patients compared to non-DM patients. Smoking habit was more common among non-DM patients (15.4% vs 7.5%, P 0.13). Stroke subtype distribution didn’t differ between two groups: Atherothrombotic etiology (18.8% in DM patients vs 14% in non-DM patients), cardioembolic (24.5% vs 28.1%), lacunar (20.7% vs 18.3%), and undetermined (35% vs 39.4%). The prevalence of transient ischaemic attack was higher among non-DM patients (33.8% vs 22.6%, P 0.19). There were no differences in stroke severity between DM patients and non-DM patients. mRS 0–2 at discharge prevalence was 74.5% vs 76%, P 0.94. NIHSS ≥8 was 25% vs 21.1%, P 0.49 respectively.

Conclusions: Our study reveals a higher prevalence of other vascular risk factors in diabetes patients. We have found no differences in relation to IS subtype and IS prognosis.