ECE2015 Eposter Presentations Diabetes (complications & therapy) (143 abstracts)
The effect of exenatide treatment on serum ghrelin levels in patients with type 2 diabetes
Figen Topyildiz 1 , Sinem Kiyici 1 , Zulfiye Gul 2 , Deniz Sigirli 3 , Metin Guclu 1 , Gurcan Kisakol 1 & Sinan Cavun 2
1Department of Internal Medicine, Sevket Yilmaz Education and Research Hospital, Bursa, Turkey; 2Department of Pharmacology, Medical Faculty, Uludag University, Bursa, Turkey; 3Department of Bio-Statistics, Medical Faculty, Uludag Univesity, Bursa, Turkey.
Aim: Ghrelin plays an important role in stimulation of food intake and long-term regulation of body weight. In present study we aimed to investigate the effect of exenatide treatment on serum ghrelin levels in patients with type 2 diabetes.
Methods: Fourteen women patients with type 2 diabetes treated with metformin and exenatide were enrolled in the study. A mixed meal test was applied to the patients while they were using their daily medications. Serum total ghrelin, glucose and insulin levels were investigated at baseline (0th min) and at the 60th, 120th, and 180th min after a mixed meal test. On the following week exenatide treatment of the patients was paused for 24 h and the same experimental procedures were repeated.
Results: Serum ghrelin levels were found suppressed significantly at the 60th and 180th min compared with baseline values after mixed meal test with exenatide treatment (P=0.042 and P=0.000 respectively). While percentage change in serum ghrelin levels after mix meal tests with and without exenatide usage were compared, no significant difference was found at the 60th and 120th min. But percent changes in serum ghrelin levels at the 180th min was statistically significant (P=0.001).
Conclusions: In present study we found that exenatide treatment suppresses serum ghrelin levels for longer time compared with the results of skipped exenatide treatment. These results suggest that the effect of exenatide on weight loss may be related with prolonged suppression of serum ghrelin levels, which is an orexigenic peptide.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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