Endocrine Abstracts

Objective: To describe the clinical characteristics of stroke in patients with prediabetes mellitus (pre-DM) and to compare them with DM and non-DM patient characteristics.

Methods: Retrospective analysis of a prospective series of acute stroke patients. Demographic and clinical characteristics were compared among the three groups, along with outcome data. Stroke severity was evaluated by modified Rankin scale (mRS) and NIHSS (NIH stroke scale).

Results: 138 patients (50 non-DM, 32 pre-DM (23%), and 56 DM). Median age was 74.5±15.35, 73.38±13.20, and 73.84±11.44 years respectively. 44% of non-DM, 53.1% of pre-DM and 58.9% of DM patients were men. The prevalence of other vascular risk factors in non-DM, pre-DM, and DM patients was: hypertension (46, 71, and 89%, **P<0.05), hypercholesterolemia (42, 65, and 69%, *P<0.05), peripheral artery disease (4, 6.2, and 7.1%), and atrial fibrillation (6, 15.6, and 16%). Smoking habit was more common in pre-DM patients (15.6% vs 14% in non-DM patients and 7.5% in DM patients). Stroke characteristics: prevalence of ischemic stroke (IS) was 88% in non-DM patients, 84.3% in pre-DM and 94.6% in DM patients (P 0.24). Transient ischemic attack was more common in non-DM patients (36.3% of IS vs 33.3% in pre-DM and 20.7% in DM patients) (P 0.28). There were no differences in stroke severity between non-DM, pre-DM, and DM patients (4.9±6.2; 4.5±6; and 4.9±5.4 NIHSS median points each group), neither in 3-month mortality (12, 12.5, and 7.1%) and in 3-month mRS (2.18±2.21; 1.81±2.2; and 1.96±1.92). rtPA success rate was 80, 66, and 33% respectively (P 0.91). P (all groups), *P (non-DM/pre-DM patients), and **P (pre-DM/DM patients).

Conclusion: Frequency of pre-DM in higher than observed in general population (10%). Pre-DM patients occupy an intermediate situation regarding vascular risk factors but has no impact on stroke outcomes.