Endocrine Abstracts

The mechanisms of myocardial damage are complex and studied insufficiently in patients with diabetes mellitus type 2 (DM2) with overweight. The contribution of adipokines leptin and resistin into the formation of diastolic dysfunction (DD) in patients with DM2 remains understudied. The purpose of the study was to evaluate the relationship between the state of leptin and resistin activity and DD in patients with DM2 with normal and overweight.

Methods: 94 patients with DM2 without systolic dysfunction were randomized into two groups: group 1 (n=34) patients with DM2 with a BMI <25 kg/m² and group 2 (n=60) patients with a BMI >25 kg/m². The levels of leptin and resistin were determined by ELISA. Echocardiographic method was performed to measure peak velocity of early diastolic filling flow (peak E), peak velocity of late diastolic filling flow (peak A), the peak E/peak A ratio (E/A), and deceleration time of early diastolic filling (DT).

Results: In group 1 the level of BMI was 24.47±0.52 kg/m², leptin 11.76±0.68 ng/ml, resistin 10.17±0.35 ng/ml, the value of the E/A 0.94±0.04, and DT 230.47±3.51 ms. In group 2 the level of BMI was 34.49±0.68 kg/m², leptin 22.75±0.49 ng/ml, resistin 14.19±0.18 ng/ml; the value of the E/A 0.81±0.03, and DT 241.72±2.18 ms. In the group 1 a reliable correlation wasn’t revealed. In the group 2 a significant correlation was revealed between E/A and leptin (R=−0.27 (P<0.05)); between DT and leptin (R=0.35 (P<0.05)); between E/A and resistin (R=−0.26 (P<0.05)); and between DT and resistin (R=0.28 (P<0.05)).

Conclusion: Hyperleptinaemia and hyperresistinaemia make a significant contribution to the DD in patients with DM2 with overweight and increase the risk of cardiovascular complications.