ECE2015 Eposter Presentations Calcium and Vitamin D metabolism (96 abstracts)
25-OH vitamin D: a predictor of clinical outcomes in primary hyperparathyroidism
Mustafa Sahin , Gozde Sengul Aycicek , Demet Corapcioglu , Rıfat Emral , Sevim Gullu , Murat Faik Erdogan , Vedia Tonyukuk Gedik , Nilgun Başkal & Ali Rıza Uysal
Ankara University, Ankara, Turkey.
Objectives: We aimed to find if there is any relationship between vitamin D levels and clinical, laboratory parameters and osteoporosis, in primary hyperparathyroidism (PHPT).
Material and methods: 128 patients with PHPT and 30 patients as a control group were analysed. Patients with PHPT were grouped due to vitamin D levels and levels low than 20 μg/ml accepted as deficiency.
Results: Patients with 25-OH vitamin D <20 μg/l were younger (P=0.043). Also they were more obese; BMI ≥30 (P=0.18) and more hypertensive (P=0.032). Metabolic syndrome (MS) incidence was higher in the patients with 25-OH vitamin D levels <20 μg/l (P=0.44). Incidence of thyroid nodules and thyroid nodule volume were similar between two groups. Also, fasting plasma glucose (FBG), HDL, LDL, triglyceride (TG), creatinine (Cr), glomerular filtration rate (GFR), TSH, T4, PTH, Ca, 24 h urinary Ca and neuthrophil/lymphocyte ratio were similar. There was no significant difference in the incidence of nephrolithiasis, osteoporosis and parathyroid adenoma size between the groups. MS incidence was higher (32.8%) in PHPT (P=0.042). 25-OH vitamin D was found to be associated with age, BMI, thyroid volume and triglyceride in regression analyses.
Conclusion: 25-OH vitamin D levels may be an indicator of hypertension (HT) and MS in PHPT. It also may be used as a treatment target in the severe disease.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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