ECE2015 Eposter Presentations Calcium and Vitamin D metabolism (96 abstracts)
The evaluation of oxidative status via the measurements of total oxidant status, total anti-oxidant status, ischaemia-modified albumin and oxidised-low density lipoprotein in patients with vitamin D deficiency
Husniye Baser 1 , Ummugulsum Can 2 , Salih Baser 3 , Bahauddin Taha Hidayetoglu 3 , Uysaler Aslan 3 , Ilker Buyuktorun 3 & Fatma Humeyra Yerlikaya 4
1Department of Endocrinology and Metabolism, Konya Education and Research Hospital, Konya, Turkey; 2Department of Biochemistry, Konya Education and Research Hospital, Konya, Turkey; 3Department of Internal Medicine, Konya Education and Research Hospital, Konya, Turkey; 4Department of Biochemistry, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey.
Introduction: Oxidative damage may be responsible for pathogenesis and complications of many diseases. Vitamin D deficiency has been suggested as a potential mediator of various extra-skeletal pathologies. However, there are limited data on anti-oxidant properties of vitamin D.
Methods: Forty-one subjects with vitamin D deficiency and 30 healthy controls were enrolled in the study. The levels of total anti-oxidant status (TAS), total oxidant status (TOS), ischaemia-modified albumin (IMA), oxidized-low density lipoprotein (ox-LDL), high-sensitivity C-reactive protein (hs-CRP) and fibrinogen were measured in the patient and control groups. These measurements were repeated in 17 patients after the replacement of vitamin D.
Results: Serum IMA and TOS levels were significantly higher (P<0.001 and P=0.035, respectively), while TAS levels were significantly lower in patients, compared with controls (P<0.001). Additionally, fibrinogen was significantly higher in patients than controls (P=0.003), while ox-LDL and hs-CRP levels were similar between two groups. After the replacement of vitamin D, TAS level was significantly increased (P=0.037), and TOS and fibrinogen levels were significantly decreased (P=0.043 and P=0.010, respectively). Vitamin D levels were negatively correlated with IMA and fibrinogen levels (r=−0.500, P<0.001 and r=−0.391, P=0.002, respectively), although positively correlated with TAS levels (r=0.430, P<0.001). No correlation was found between vitamin D levels, and TOS, ox-LDL and hs-CRP levels.
Conclusions: In this study, while serum IMA, TOS and fibrinogen levels were increased, TAS levels were seen to be decreased in patients with vitamin D deficiency. These results suggest that oxidative/anti-oxidative balance shifts in favours of oxidative status in vitamin D deficiency.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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