ECE2015 Eposter Presentations Adrenal cortex (94 abstracts)
The effect of oxidative stress to cardiovascular risk profile among non-functional adrenal incidentaloma patients
Hanife Bolat 1 , Kamile Gul 2 , Gulizar Sokmen 3 , Murat Sahin 2 , Ergul Kurutas 4 , Ayten Oguz 2 , Abdullah Sokmen 3 , Dilek Tuzun 2 , Safiye Seyma Taner 4 & Omer Faruk Akgul 1
1Department of Internal Medicine, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey; 2Department of Endocrinology and Metabolism, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey; 3Department of Cardiology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey; 4Department of Biochemistry, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
Aim: In this study our aim was to investigate the effects of non-functional adrenal incidentalomas to cardio-metabolic risk factors and endothelial function.
Materials and methods: Our study involved 30 patients with non-functional adrenal incidentaloma (patient group), and two control groups without adrenal incidentaloma (control group 1 involved 26 patients have DM and/or HT and control group 2 involved 24 healthy control). Metabolic parameters (fasting blood glucose and lipid profile), hsCRP, oxidative stress parameters such as malondialdehyde (MDA), nitric oxide (NO), nitrotyrosine (3-NTx), and antioxidants parameters such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and melatonin were evaluated in all participants.
Results: When we compared the patient and control groups; hsCRP, oxidative stress parameters (MDA, NO, and 3-NTx) were significantly higher in patient group (P<0.001) but antioxidant parameters such as melatonin, GPx, and SOD were significantly lower in patient group (P<0.001). Cortisol levels after 1 mg dexamethasone suppression test were significantly higher in patient group (P<0,01). There was a significant positive correlation between cortisol levels after 1 mg dexamethasone suppression test and hsCRP, MDA, NO, and 3-NTx levels (P<0.05) and there was a significant negative correlation between cortisol levels after 1 mg dexamethasone suppression test and melatonin, GPx, and SOD levels (P<0.001).
Conclusion: Adrenal incidentalomas are usually thought to be benign and asymptomatic lesions. But recent studies reported that autonomic cortisol secretion was higher than expected in incidentalomas and they have increased cardiovascular risk. But it is not clear whether adrenal incidentalomas increase the atherosclerosis and cardio-metabolic risk or this adrenal tumours mostly seen in patients that have cardio-metabolic risks. According to the data obtained from this study; we suggest that the oxidative stress increases markedly in the patients with non-functional adrenal incidentalomas, so this process leads the atherosclerosis eventually. Moreover we showed that non-functional adrenal incidentaloma patients have higher cortisol levels when compared both with healthy controls and patients that have cardiovascular risk factors. Therefore we suggest to consider the factors that mentioned above when evaluating the non-functional adrenal incidentaloma patients.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more