Endocrine Abstracts

Introduction: Autoimmune thyroid disease (AITD) with elevated antithyroid peroxidase antibodies (aTPO) levels appear in 12–25% of women and is observed more frequently in patients with polycystic ovary syndrome and endometriosis. Some data showed the interference of elevated thyroid antibodies and infertility and worsening quality of life.

Aim: The aim of the study was to determine serum leptin levels among AITD(+) and AITD(−) patients.

Material and methods: In the study were involved 74 patients. All women were hospitalized in Department of Gynaecological Endocrinology because of irregular menses or/and hypo/hypermenorrhoea. In all patients hormonal profile was determined by serum levels of: aTPO, TSH, fT4, FSH, LH, estradiol, progesterone and testosterone. Patients were divided into two groups: AITD positive (aTPO+) and AITD negative (aTPO−).

RESULTS: Leptin serum concentration (ng/ml) was significantly higher in AITD(+) compared to AITD(−): 17.13±7.66 to 12.78±7.28 (P<0.05). LH level (mIU/ml) was different in analysed groups: 7.13±8.39 in AITD(+), 4.3±3.06 in AITD(−) (P<0.05).

There were not found differences in age between both groups: 37.56 years ±7.67 in AITD(+), 34.73 years ±6.14 in AITD(−) (P=0.1). BMI was similar in both groups: AITD(+) vs AITD(−) was: 22±3.49 vs 23.5±4.35 (P=0,29). TSH and fT4 did not differ between groups. TSH (uIU/ml) in AITD(+) was 1.467±0.79, in AITD(−) 1.32±0,73 (P=0.44); fT4 (pmol/l) in AITD(+) was 13.71±2.56, in AITD(−) was 13.66±1.68 (P=0.92).

There were no differences in serum concentration of FSH, estradiol, progesterone and testosterone between both groups.

Conclusions: Leptin and LH serum concentration are higher in patients with autoimmune thyroid disease in euthyroid state than in patients without autoimmune thyroid disease.