ECE2014 Poster Presentations Thyroid (non-cancer) (125 abstracts)
Body mass analysis in patients with Hashimoto thyroiditis
Anna Poplawska-Kita 1 , Katarzyna Siewko 1 , Beata Telejko 1 , Maria Kosciuszko-Zdrodowska 1 , Justyna Hryniewicka 1 , Malgorzata Szelachowska 1 , Robert Milewski 2 & Maria Górska 1
1Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Bialystok, Poland, 2Department of Statistics and Medical Informatics, Medical University, Bialystok, Poland.
Introduction: Thyroid hormones deficiency in the course of subclinical and overt hypothyroidism is frequently related to the increased body mass, reduced thermogenesis and metabolic rate however the pathogenesis of improper body mass in Hashimoto thyroiditis (HT) patients is still an open question. Therefore, in the present study we compared body mass and body composition between the patients with Hashimoto thyroiditis who were in clinical and hormonal euthyreosis and healthy individuals who had never been treated for autoimmune thyroid disorders.
Material and methods: The group studied consisted of 53 patients with HT in euthyreosis and 28 healthy individuals. All the patients underwent thyroid ultrasonography and body mass analysis with the use of a medical analyzer InBody 200. Blood samples were also analyzed for TSH and anti-thyroid antibodies.
Results: The patients with HT had higher body mass (P=0.008), BMI (P=0.02), WHR (0.01) and fat mass (P=0.02) than had the controls. In HT group increased body mass was observed in 72% of the patients (overweight in 38% and obesity in 35% of them), as compared with 38% of overweight/obesity in the control group. Thyroid volume was significantly lower (P=0.01) and anti-peroxidase antibodies level was two times higher in the group with the treatment period >2 years, but the patients with relatively short treatment period were 7 kg heavier and their fat mass was 6 kg higher than in the subjects treated longer than 2 years.
Conclusions: Our results suggest that the patients with HT, even in euthyreosis, have significantly higher body mass, BMI, WHR and fat mass than healthy individuals, which is probably associated with previous disturbances that led to the increase in fat mass at the stage of hypothyroidism. The observed changes tend to normalize during L-thyroxine replacement therapy.
Keywords: Thyroid, thyroiditis, body mass index, thyrotropin
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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