Endocrine Abstracts

Aim and Objectives: Is Hashimoto thyroiditis (HT) different from thyroiditis with only antithyroglobulin antibodies (T-ATG)?

Material and method: i). Diagnosis: ATPO >34 ui/ml = HT; ATPO normal with high ATG (>34 ui/ml) =T-ATG. ii). Thyroid function: TSH. iii). Patients: HT=1293, T-ATG=92. iv). Statistical analysis: Student tα, linear correlation tests.

Results: A. HT: I. ATPO: Average =691.38. II. Linear correlation ATPO-TSH: r=0.11, P<0,001. III. ATPO by function: 1. Euthyroidism (EUT) =575 patients (44.47%), average =586.33, hypothyroidism (HOT) =542 (41.92%), average =846.11, hyperthyroidism (HIT) =176 (13.61%), average =558.09, lower than EUT. 2. Statistical differences: ATPO-EUT vs ATPO-HOT: P<<0.001, ATPO-EUT vs ATPO-HIT: P=0.7. IV. ATG: Average: 465.42. V. Linear correlation ATG-TSH: r=0.096, P<0.01. VI. ATG by function: 1. EUT average =364.98, HOT average =599.16, HIT average =325, lower than EUT. 2. Statistical differences: ATG-EUT vs ATG-HOT: P<<0,001, ATG-EUT vs ATG-HIT: P=0.7.

B. T-ATG: I. ATPO: Average =11.09; s.d. =8,49. II. T-ATG: Average =446.2. III. Linear correlation ATG-TSH: r=− 0.12; No correlation. IV. ATG by function: 1. EUT =55 patients (59.78%, more than in HT, z=− 2.7, P=0.006), average =442.67, HOT =24 (26.09%, less than in HT, P<<0.001), average =314.27, lower that EUT, HIT =13 (14.13%, same as HT), average =729.412, higher than EUT. 2. No statistical differences (P>0.05) ATG-EUT vs ATG-HOT, ATG-EUT vs ATG-HIT.

Conclusions: i). Significant correlation exists between thyroid function and both ATPO and ATG in HT: in hypothyroid patients, ATPO/ATG were higher than in hyperthyroid and euthyroid patients. ii). HT vs T-ATG evolve with more hypothyroidism vs Euthyroidism. iii). ATG in T-ATG had no relationship with thyroid function. iv). Thyroiditis with only ATG is a different thyroiditis comparing with Hashimoto thyroiditis.