ECE2014 Poster Presentations Steroid metabolism and action (12 abstracts)
Tissue cortisol vs lipolysis in ICU patients
Ioannis Ilias 1 , Dimitra Vassiliadi 2 , Maria Theodorakopoulou 2 , Nikitas Nikitas 2 , Marinela Tzanela 3 , Sofia Apollonatou 2 , Stylianos Tsagarakis 3 & Ioanna Dimopoulou 2
1Endocrine Unit, Elena Venizelou Hospital, Athens, Greece; 2Second Department of Intensive Care, University of Athens Medical School, Attikon Hospital, Athens, Greece; 3Endocrine Department, Evangelismos Hospital, Athens, Greece.
Introduction: The interplay of cortisol (F) and adipose tissue is complex and in many aspects is still obscure. Plasma F has been shown to be positively associated with lipolysis.
Aim: To study in adipose tissue indices of lipolysis vs tissue F with microdialysis (MD).
Subjects and methods: We studied 46 mechanically ventilated patients with a diagnosis of septic/non-septic shock, systemic inflammatory response syndrome or severe sepsis. Upon ICU admission a MD catheter was inserted under sterile conditions into the subcutaneous adipose tissue of the upper thigh. Excluding patients on steroid therapy, on day 2 (n=26), day 3 (n=24) and day 4 (n=22) MD samples were collected six times per day for MD glycerol (MD GLYC; used as an index of lipolysis) and tissue F. The mean of these six collections was used for analysis (normal values for adipose tissue GLYC <200 μmol/l). Statistics were done with Spearman’s rank correlation.
Results: Most samplings (44/72) indicated accentuated lipolysis with above-normal MD GLYC levels. MD GLYC was weakly correlated to MD F (r=0.246, P=0.038).
Discussion: We verified the well-known association (though modestly so) between lipolysis and F (and in particular with interstitial/tissue levels of it). Changes in interstitial/tissue F may not be reflected in plasma (total) F concentrations. Thus it is interesting that we observed an – albeit weak – association between tissue lipolysis (via MD GLYC levels) and MD F.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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