ECE2014 Poster Presentations Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) (108 abstracts)
Serum prolactin in advanced chronic liver disease
Claudia Ress 1 , Pirmin Maeser 1 , Alexander Tschoner 1 , Lorin Loacker 3 , Karin Salzmann 1 , Gabriele Staudacher 1 , Andreas Melmer 1 , Heinz Zoller 2 , Wolfgang Vogel 2 , Andrea Griesmacher 3 , Herbert Tilg 1 , Ivo Graziadei 4 & Susanne Kaser 1
1Department of Medicine I, Medical University Innsbruck, Innsbruck, Austria; 2Department of Medicine II, Medical University Innsbruck, Innsbruck, Austria; 3Central Institute for Medical and Chemical Laboratory Diagnostics, Medical University Innsbruck, Innsbruck, Austria; 4Division of Internal Medicine, Hospital Hall i Tirol, Hall, Austria.
Introduction: Hyperprolactinemia is a frequent endocrine disorder with well known harmful effects on the reproductive system and bone metabolism. Besides prolactinomas several drugs and disorders such as renal failure and hypothyroidism have been shown to cause hyperprolactinemia. Based on former studies liver cirrhosis has also been suggested to cause hyperprolactinemia while mechanisms have not been identified yet. In this study we set out to investigate the prevalence and predictors of hyperprolactinemia in 178 patients with liver cirrhosis of different etiologies.
Results: Eighteen from 178 patients, seven females and 11 males, displayed elevated serum prolactin levels. When patients who took medication or suffered from co-morbidities that are known to potentially cause hyperprolactinemia were excluded, only three males from 55 patients without confounding factors had increased serum prolactin levels. Prolactin levels were similar in patients with liver cirrhosis of different etiologies.
Conclusion: Our data suggest that hyperprolactinemia is not commonly found in patients with liver cirrhosis but is mostly associated with intake of drugs or presence of comorbidites which are known to potentially cause hyperprolactinemia. We thus hypothesize that in contrast to former studies liver cirrhosis is not a common cause of hyperprolactinemia and that in the absence of co-morbidities or drugs that are known to potentially increase prolactin levels marked hyperprolactinemia needs further investigation in patients with liver cirrhosis.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more