ECE2014 Poster Presentations Bone and Osteoporosis (36 abstracts)
The 10-year absolute fracture risk and central DXA correlations in 505 Romanian menopausal women
Mara Carsote 1, , Valentin Radoi 2 , Alexandra Mihai 1 , Andreea Geleriu 1 , Ionela Baciu 1, , Cristina Capatana 1, , Diana Paun 1, & Catalina Poiana 1,
1Parhon Institute, Bucharest, Romania; 2Davila UMPh, Bucharest, Romania.
Introduction: The new tool FRAX indicated risk of fracture, using or not DXA which is the golden standard for osteoporosis diagnosis.
Aim: We analyzed the lumbar DXA correlations with 10-year fragility fracture risk probability.
Material and method: A cross sectional study in postmenopausal women was designed. They were osteoporosis free at baseline; none of them has previously been treated for osteoporosis. The anamnesis, the anthropometric parameters, as well as bone metabolism were assessed. The FRAX calculator (Romanian version) was used without bone mineral density (BMD) at femoral neck. Central DXA (Lunar Prodigy) was performed at lumbar spine. The WHO criteria were used. The statistical tests used SPSS (statistical significance was at P value<0.05).
Results: 505 patients were enrolled. The meadian age was 57 years. The 10-year probability of major osteoporotic fractures was 4.5%, and for hip fractures was 1.1%. The 10-year risk increases from normal DXA group to osteoporosis. The average lumbar BMD was 1.01±0.1 g/cm2. The linear regression between lumbar BMD and 10-year major osteoporotic fractures risk was: r=−0.2 (P<0.05) respectively for hip fractures was: r=0.2 (P<0.05). The value of r in each group of women having normal DXA, or osteopenia, or osteoporosis was not statistically significant. Regardless the group of patients, the hip fracture risk was lower than major osteoporotic fracture risk based on FRAX model. If using the femoral neck BMD, the fracture risk based on FRAX was not different to the risk based on FRAX model without this value.
Discussions: Poor correlation was found between FRAX risk estimation and lumbar DXA in WHO groups. The entire cohort proved highly statistically significant value of r.
Conclusion: The use of FRAX in relationship with gold standard DXA is a complementary evaluation in order to assess the fracture risk.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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