ECE2014 Poster Presentations Obesity (53 abstracts)
Dietary fat alters the expression of cortistatin and ghrelin systems in the PBMCs of elderly subjects: Putative implications in the postprandial inflammatory response
Manuel D. Gahete 1, , Raul M. Luque 1 , Elena M. Yubero-Serrano 2 , Cristina Cruz-Teno 2 , Alejandro Ibanez-Costa 1 , Javier Delgado-Lista 2 , Francisco Gracia-Navarro 1 , Francisco Perez-Jimenez 2 , Justo P. Castaño 1 & Jose Lopez-Miranda 2
1Department of Cell Biology, Physiology and Immunology, University of Cordoba, Reina Sofia University Hospital, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), and CIBER Fisiopatol, Cordoba, Spain; 2Lipid and Atherosclerosis Research Unit, Reina Sofia University Hospital, University of Cordoba, IMIBIC and CIBERObn, Cordoba, Spain.
Dietary fat influences systemic inflammatory status, which, in turn, determines the progression of age-associated diseases. Peripheral blood mononuclear cells (PBMCs) comprise a subset of white blood cells placed at the crossroad between diet and inflammation, in that they play a key role in the immune/inflammatory system and their gene expression pattern is influenced by diet. Since the somatostatin (SST), cortistatin (CORT) and ghrelin systems have been shown to modulate the inflammatory response, in this study, a nutrigenomic, inflammation-related PBMC-based approach was applied to comprehensively characterize the presence/abundance of the components of the SST/CORT and ghrelin systems in PMBCs, as well as to understand their regulation under diets with different fat composition, and during the postprandial phase in elderly subjects. Our data indicate that the majority of components of the SST/CORT and ghrelin systems are present in the human PBMCs. Particularly, CORT and the SST/CORT receptors (sst2, sst3, sst5 and sst5TMD4), as well as ghrelin, its acylating enzyme (GOAT), In1-ghrelin variant and GHSR1b were detected in PBMCs. Of note, their expression was altered both, in the long-term by diet composition, and in the short-term, during the postprandial phase, suggesting a potential relevant role of these systems in regulating PBMCs response to nutrient intake. Of particular relevance is the postprandial elevation of the expression of CORT, sst2 and sst5 in PBMCs of subjects under an n-3 PUFAs-enriched diet, which could help to explain the positive effects of this diet in reducing the inflammatory response.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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